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    [platne_od] => 13.03.2020 21:32:00
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Forensic laboratory of biologically active substances

Technická 3, 166 28 Prague 6

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Employees


 
Students


 
Alumni




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Steroids
Instrumental analysis
Immunochemical diagnostics

New psychoactive substances (NPS)

General information

Categorization and screening of NPS
Legislative related to NPS

Pharmacology

Pharmacodynamics
Pharmacokinetics

Analysis

Electrophoresis
Enantioseparation

Synthesis

Components for immunochemical assays
Preparation of analytical standards


Forensic and toxicological research
Synthesis of metabolites
Precursors
Drug profiling
Quantitative analysis of illicit substances in real samples
Drug counterfeits

Neurotransmiters
Microdialyzate analysis
Diagnostics and potential new drugs

Novel psychopharmaceuticals
Cannabinoids
Bioactive amines
Inhibitors of tryptophan metabolism

Natural bioactive substances
Active compounds from Cannabis plants
Etnobotanics
"Magic mushrooms" - Psilocybe mushrooms

Psilocybin
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Ing. Martin Kuchař, Ph.D.

Toxikologie a analýza drog - N320080
Drogy a závislosti/Drugs and Addictions - P342002/AP342002

Ing. Radek Jurok, Ph.D.

Organická chemie A - B110001
Organická chemie B - B110002
Laboratoř organické chemie I - B110005
Laboratoř organické chemie II - B110006
Laboratoř specializace - syntéza léčiv - M110010
Laboratorní projekt programu SVL II - M150009

PharmDr. Petra Cihlářová, Ph.D.

Rostlinné léky a tradiční medicina - N342025
Moderní separační metody s hmotnostní detekcí/Recent separation methods with mass-spectrometry detection - P342005/AP342005
Biologicky aktivní přírodní látky/Bioactive Natural Compounds - N342009/S342009/S342009A

Mgr. Edita Kofroňová, Ph.D.

Izolace a identifikace přírodních látek - N342022
Optimalizace kapalinové chromatografie - D342002
Plynová chromatografie a hmotnostní detektor - D342005

Ing. Elena Prokudina, Ph.D.

Izolace a identifikace přírodních látek - N342022
Izolace a separace molekul - M342005
Optimalizace kapalinové chromatografie - D342002
Plynová chromatografie a hmotnostní detektor - D342005
Moderní separační metody s hmotnostní detekcí/Recent separation methods with mass-spectrometry detection - P342005/AP342005
Laboratoř pro střední školy - CZV00012

Ing. Natálie Kolderová

Chemická informatika - N143013

Mgr. Alžběta Nemeškalová

Laboratoř forenzní chemie - M402039
Laboratoř separačních metod - M402042

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2024
Journal articles:




Dobšíková, K.; Taušová, T.; Fagan, P.; Paškanová, N.; Kuchař, M.; Čejka, J.; Setnička, V. Solid-State Vibrational Circular Dichroism: Methodology and Application for Amphetamine Derivatives. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2024, 305, 123486.
https://doi.org/10.1016/j.saa.2023.123486






2023
Journal articles:




Dobšíková, K.; Michal, P.; Spálovská, D.; Kuchař, M.; Paškanová, N.; Jurok, R.; Kapitán, J.; Setnička, V. Conformational Analysis of Amphetamine and Methamphetamine: A Comprehensive Approach by Vibrational and Chiroptical Spectroscopy. Analyst 2023, 148 (6), 1337–1348. 
https://doi.org/10.1039/D2AN02014A





Di Bartolomeo, M.; Stark, T.; Di Martino, S.; Iannotti, F. A.; Ruda-Kucerova, J.; Romano, G. L.; Kuchar, M.; Laudani, S.; Palivec, P.; Piscitelli, F.; Wotjak, C. T.; Bucolo, C.; Drago, F.; Di Marzo, V.; D’Addario, C.; Micale, V. The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology. Int. J. Mol. Sci. 2023, 24 (4), 3907. 
https://doi.org/10.3390/ijms24043907





Dobšíková, K.; Javorská, Ž.; Paškan, M.; Spálovská, D.; Trembulaková, P.; Herciková, J.; Kuchař, M.; Kozmík, V.; Kohout, M.; Setnička, V. Enantioseparation and a Comprehensive Spectroscopic Analysis of Novel Synthetic Cathinones Laterally Substituted with a Trifluoromethyl Group. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2023, 291, 122320. 
https://doi.org/10.1016/j.saa.2023.122320





Castelli, V.; Lavanco, G.; D’Amico, C.; Feo, S.; Tringali, G.; Kuchar, M.; Cannizzaro, C.; Brancato, A. CBD Enhances the Cognitive Score of Adolescent Rats Prenatally Exposed to THC and Fine-Tunes Relevant Effectors of Hippocampal Plasticity. Front. Pharmacol. 2023, 14.
https://doi.org/10.3389/fphar.2023.1237485





Tringali, G.; Lavanco, G.; Castelli, V.; Pizzolanti, G.; Kuchar, M.; Currò, D.; Cannizzaro, C.; Brancato, A. Cannabidiol Tempers Alcohol Intake and Neuroendocrine and Behavioural Correlates in Alcohol Binge Drinking Adolescent Rats. Focus on Calcitonin Gene‐related Peptide’s Brain Levels. Phyther. Res. 2023, 37 (11), 4870–4884. 
https://doi.org/10.1002/ptr.7972





Tylš, F.; Vejmola, Č.; Koudelka, V.; Piorecká, V.; Kadeřábek, L.; Bochin, M.; Novák, T.; Kuchař, M.; Bendová, Z.; Brunovský, M.; Horáček, J.; Pálení ček, T. Underlying Pharmacological Mechanisms of Psilocin-Induced Broadband Desynchronization and Disconnection of EEG in Rats. Front. Neurosci. 2023, 17.
https://doi.org/10.3389/fnins.2023.1152578





Nikolič, M.; Viktorin, V.; Zach, P.; Tylš, F.; Dudysová, D.; Janků, K.; Kopřivová, J.; Kuchař, M.; Brunovský, M.; Horáček, J.; Páleníček, T. Psilocybin Intoxication Did Not Affect Daytime or Sleep-Related Declarative Memory Consolidation in a Small Sample Exploratory Analysis. Eur. Neuropsychopharmacol. 2023, 74, 78–88.
https://doi.org/10.1016/j.euroneuro.2023.04.019





Syrová, K.; Šíchová, K.; Danda, H.; Lhotková, E.; Jorratt, P.; Pinterová-Leca, N.; Vejmola, Č.; Olejníková-Ladislavová, L.; Hájková, K.; Kuchař, M.; Horáček, J.; Páleníček, T. Acute Pharmacological Profile of 2C-B-Fly-NBOMe in Male Wistar Rats—Pharmacokinetics, Effects on Behaviour and Thermoregulation. Front. Pharmacol. 2023, 14. 
https://doi.org/10.3389/fphar.2023.1120419





Pospíšilová, E.; Paškanová, N.; Kuchař, M.; Shishkanova, T. V. Potentiometric Determination of Mephedrone in Oral Fluids with Ion‐selective Membranes. Electroanalysis 2023, 35 (6). 
https://doi.org/10.1002/elan.202200468





Castelli, V.; Lavanco, G.; Feo, S.; D’Amico, C.; Micale, V.; Kuchar, M.; Plescia, F.; Brancato, A.; Cannizzaro, C. Prenatal Exposure to Δ9-Tetrahydrocannabinol Affects Hippocampus-Related Cognitive Functions in the Adolescent Rat Offspring: Focus on Specific Markers of Neuroplasticity. Pharmaceutics 2023, 15 (2), 692.
https://doi.org/10.3390/pharmaceutics15020692





Jurásek, B.; Fagan, P.; Dolenský, B.; Paškanová, N.; Dobšíková, K.; Raich, I.; Jurok, R.; Setnička, V.; Kohout, M.; Čejka, J.; Kuchař, M. A Structural Spectroscopic Study of Dissociative Anaesthetic Methoxphenidine. New J. Chem. 2023, 47 (9), 4543–4551.
https://doi.org/10.1039/D2NJ06126K





Dobšíková, K.; Spálovská, D.; Kuchař, M.; Paškanová, N.; Setnička, V. Indazole-Derived Synthetic Cannabinoids: Absolute Configuration Determination and Structure Characterization by Circular Dichroism and DFT Calculations. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2023, 291, 122373.
https://doi.org/10.1016/j.saa.2023.122373






2022
Journal articles:




Jurásek, B.; Rimpelová, S.; Babor, M.; Čejka, J.; Bartůněk, V.; Kuchař, M. Intriguing Cytotoxicity of the Street Dissociative Anesthetic Methoxphenidine: Unexpected Impurities Spotted. International Journal of Molecular Sciences  2022, 23 (2083), 1–15.
https://doi.org/10.3390/IJMS23042083





Viktorin, V.; Griškova-Bulanova, I.; Voicikas, A.; Dojčánová, D.; Zach, P.; Bravermanová, A.; Andrashko, V.; Tylš, F.; Korčák, J.; Viktorinová, M.; Koudelka, V.; Hájková, K.; Kuchař, M.; Horáček, J.; Brunovský, M.; Páleníček, T. Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience. Journal of Personalized Medicine 2022, 12 (6).
https://doi.org/10.3390/jpm12061004





van Elk, M.; Fejer, G.; Lempe, P.; Prochazckova, L.; Kuchar, M.; Hajkova, K.; Marschall, J. Effects of Psilocybin Microdosing on Awe and Aesthetic Experiences: A Preregistered Field and Lab-Based Study. Psychopharmacology (Berl) 2022, 239 (6), 1705–1720.
https://doi.org/10.1007/s00213-021-05857-0.





Šíma, M.; Bobek, D.; Cihlářová, P.; Ryšánek, P.; Roušarová, J.; Beroušek, J.; Kuchař, M.; Vymazal, T.; Slanař, O. Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin. Pharmaceutics 2022, 14 (8), 1627.
https://doi.org/10.3390/pharmaceutics14081627





Sanz, C.; Cavanna, F.; Muller, S.; de la Fuente, L.; Zamberlan, F.; Palmucci, M.; Janeckova, L.; Kuchar, M.; Carrillo, F.; García, A. M.; Pallavicini, C.; Tagliazucchi, E. Natural Language Signatures of Psilocybin Microdosing. Psychopharmacology (Berl) 2022, 239 (9), 2841–2852.
https://doi.org/10.1007/s00213-022-06170-0





Kretschmer, J.; David, T.; Dračínský, M.; Socha, O.; Jirak, D.; Vít, M.; Jurok, R.; Kuchař, M.; Císařová, I.; Polasek, M. Paramagnetic Encoding of Molecules. Nature Communications 2022, 13 (1), 1–12.
https://doi.org/10.1038/s41467-022-30811-9





Cavanna, F.; Muller, S.; de la Fuente, L. A.; Zamberlan, F.; Palmucci, M.; Janeckova, L.; Kuchar, M.; Pallavicini, C.; Tagliazucchi, E. Microdosing with Psilocybin Mushrooms: A Double-Blind Placebo-Controlled Study. Translation Psychiatry 2022, 12 (1), 1–11.
https://doi.org/10.1038/s41398-022-02039-0





Brancato, A.; Castelli, V.; Lavanco, G.; D’Amico, C.; Feo, S.; Pizzolanti, G.; Kuchar, M.; Cannizzaro, C. Social Stress under Binge-like Alcohol Withdrawal in Adolescence: Evidence of Cannabidiol Effect on Maladaptive Plasticity in Rats. Psychological Medicine 2022, 1–13.
https://doi.org/10.1017/S0033291722002744





Bavlovič Piskáčková, H.; Nemeškalová, A.; Kučera, R.; Pedersen-Bjergaard, S.; Najmanová, V.; Štěrbová-Kovaříková, P.; Kuchař, M.; Sýkora, D. Advanced Microextraction Techniques for the Analysis of Amphetamines in Human Breast Milk and Their Comparison with Conventional Methods. Journal of Pharmaceutical and Biomedical Analysis 2022, 210 (114549).
https://doi.org/10.1016/j.jpba.2021.114549






2021
Journal articles:




Kosović, E.; Sýkora, D.; Kuchař, M. Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution. Pharmaceutics 2021, 13 (3).
https://doi.org/10.3390/pharmaceutics13030412.




Šuláková, A.; Nykodemová, J.; Palivec, P.; Jurok, R.; Rimpelová, S.; Leonhardt, T.; Šíchová, K.; Páleníček, T.; Kuchař, M. 25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. Elegans—Structure Determination and Synthesis of the Most Abundant Metabolites. Metabolites 2021, 11 (4).
https://doi.org/10.3390/metabo11040212




Šuláková, A.; Nykodemová, J.; Palivec, P.; Jurok, R.; Rimpelová, S.; Leonhardt, T.; Šíchová, K.; Páleníček, T.; Kuchař, M. 25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. Elegans—Structure Determination and Synthesis of the Most Abundant Metabolites. Metabolites 2021, 11 (4).
https://doi.org/10.3390/metabo11040212




Fagan, P.; Spálovská, D.; Jurok, R.; Kuchař, M.; Schrenková, V.; Setnička, V. Structural Analysis of MDMA in Solution by Methods of Chiroptical Spectroscopy Supported by DFT Calculations. Vib. Spectrosc. 2021, 114 (103255).
https://doi.org/10.1016/j.vibspec.2021.103255




Šíma, M.; Michaličková, D.; Ryšánek, P.; Cihlářová, P.; Kuchař, M.; Lžičařová, D.; Beroušek, J.; Hartinger, J. M.; Vymazal, T.; Slanař, O. No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses. Pharmaceutics 2021, 13 (8).
https://doi.org/10.3390/pharmaceutics13081156




Nykodemová, J.; Šuláková, A.; Palivec, P.; Češková, H.; Rimpelová, S.; Šíchová, K.; Leonhardt, T.; Jurásek, B.; Hájková, K.; Páleníček, T.; Kuchař, M. 2C-B-Fly-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and c. Elegans: Confirmation with Synthesized Analytical Standards. Metabolites 2021, 11 (11), 1–18.
https://doi.org/10.3390/metabo11110775




Fagan, P.; Spálovská, D.; Kuchař, M.; Černohorský, T.; Komorousová, L.; Kocourková, L.; Setnička, V. Ecstasy Tablets: Rapid Identification and Determination of Enantiomeric Excess of MDMA. Forensic Chem. 2021, 26 (100381).
https://doi.org/10.1016/j.forc.2021.100381




Spálovská, D.; Pekárek, T.; Kuchař, M.; Setnička, V. Comparison of Genuine, Generic and Counterfeit Cialis Tablets Using Vibrational Spectroscopy and Statistical Methods. J. Pharm. Biomed. Anal. 2021, 206.
https://doi.org/10.1016/j.jpba.2021.114383




Spálovská, D.; Paškan, M.; Jurásek, B.; Kuchař, M.; Kohout, M.; Setnička, V. Structural Spectroscopic Study of Enantiomerically Pure Synthetic Cathinones and Their Major Metabolites. New J. Chem. 2021, 45 (2), 850–860.
https://doi.org/10.1039/d0nj05065b




Di Bartolomeo, M.; Stark, T.; Maurel, O. M.; Iannotti, F. A.; Kuchar, M.; Ruda-Kucerova, J.; Piscitelli, F.; Laudani, S.; Pekarik, V.; Salomone, S.; Arosio, B.; Mechoulam, R.; Maccarrone, M.; Drago, F.; Wotjak, C. T.; Di Marzo, V.; Vismara, M.; Dell’Osso, B.; D’Addario, C.; Micale, V. Crosstalk between the Transcriptional Regulation of Dopamine D2 and Cannabinoid CB1 Receptors in Schizophrenia: Analyses in Patients and in Perinatal Δ9-Tetrahydrocannabinol-Exposed Rats. Pharmacol. Res. 2021, 164 (July 2020), 105357.
https://doi.org/10.1016/j.phrs.2020.105357




Shishkanova, T. V.; Štěpánková, N.; Tlustý, M.; Tobrman, T.; Jurásek, B.; Kuchař, M.; Trchová, M.; Fitl, P.; Vrňata, M. Electrochemically Oxidized 15-Crown-5 Substituted Thiophene and Host-Guest Interaction with New Psychoactive Substances. Electrochim. Acta 2021, 373 (137862).
https://doi.org/10.1016/j.electacta.2021.137862




Charalambous, C.; Havlickova, T.; Lapka, M.; Puskina, N.; Šlamberová, R.; Kuchar, M.; Sustkova-Fiserova, M. Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. Int. J. Mol. Sci. 2021, 22 (5), 1–22.
https://doi.org/10.3390/ijms22052397




Belhacova, L.; Bibova, H.; Marikova, T.; Kuchar, M.; Zouzelka, R.; Rathousky, J. Removal of Ampicillin by Heterogeneous Photocatalysis: Combined Experimental and DFT Study. Nanomaterials 2021, 11 (8), 1992.



https://doi.org/10.3390/nano11081992









2020
Journal articles:




Madsen, M. K.; MacDonald Fisher, P.; Stenbæk, D. S.; Kristiansen, S.; Burmester, D.; Lehel, S.; Páleníček, T.; Kuchař, M.; Svarer, C.; Ozenne, B.; Knudsen, G. M.  A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Europian Neuropsychopharmacology 2020, in press (available online).





Králík, F.; Fagan, P.; Kuchař, M.; Setnička, V. Structure of heroin in a solution revealed by chiroptical spectroscopy. Chirality 2020, in press (available online).




Huml, L.; Havlová, D.; Longin, O.; Staňková, E.; Holubová, B.; Kuchař, M.; Prokudina, E.; Rottnerová, Z.; Zimmermann, T.; Drašar, P.; Lapčík, O.; Jurášek, M. Stanazolol derived ELISA as a sensitive forensic tool for the detection of multiple 17α-methylated anabolics. Steroids 2020, 155, in press (available online).





Hájková, K.; Jurásek, B.; Čejka, J.; Štefková, K.; Páleníček, T.; Sýkora, D.; Kuchař, M. Synthesis and identification of deschloroketamine metabolites in rats' urine and a quantification method for deschloroketamine and metabolites in rats' serum and brain tissue using liquid chromatography tandem mass spectrometry. Drug Testing and Analysis 2020, 12 (3), 343–360.




Shishkanova, T. V.; Vatrsková, L; Spálovská, D.; Králík, F.; Cuřínová, P.; Winkler, M.; Budka, J.; Jurásek, B.; Kuchař, M.; Setnička, V. Complexation of cathinones by 4-tert-butylcalix[4]arene tetra-acetate as a possible technique for forensic analysis. Forensic Toxicology 2020, 38, 70–78.





2019
Journal articles:




Knytl, P.;Voráčková, V.; Dorazilová, A.; Rodriguez, M.; Cvrčková, A.; Kofroňová, E.; Kuchař, M.; Kratochvílová, Z.; Šustová, P.; Čerešňáková, S.; Mohr, P. Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings. Frontiers in Psychiatry 2019, 10, article 390.




Guricova, M.; Pinc, J.; Malinčík, J.; Rak, J.; Kuchař, M.; Bartůněk, V. Rare earth nanofluorides: synthesis using ionic liquids. Reviews in Inorganic Chemistry 2019, 39 (2), 77–90.




Uthaug, M. V.; Lancelotta, R.; van Oorsouw, K.; Kuypers, K. P. C.; Mason, N.; Rak, J.; Šuláková, A.; Jurok, R.; Maryška, M.; Kuchař, M.; Páleníček, T.; Riba, J.; Ramaekers, J. G. A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology 2019, 236 (9), 2653–2666.




Nemeškalová, A.; Bursová, M.; Sýkora, D.; Kuchař, M.; Čabala, R.; Hložek, T. Salting out assisted liquid-liquid extraction for liquid chromatography tandem-mass spectrometry determination of amphetamine-like stimulants in meconium. Journal of Pharmaceutical and Biomedical Analysis 2019, 172, 42–49.




Drazanova, E.; Ruda-Kucerova, J.; Kratka, L.; Stark, T.; Kuchar, M.; Maryska, M.; Drago, F.; Starcuk Jr., Z.; Micale, V. Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats. Scientific Reports 2019, 9, article 6062.




Spálovská, D.; Maříková, T.; Kohout, M.; Králík, F.; Kuchař, M.; Setnička, V. Methylone and pentylone: structural analysis of new psychoactive substances. Forensic Toxicology 2019, 37, 366–377.




Stark, T.; Giurdanella, G.; Pekarik, V.; Kuchar, M.; Babinska, Z.; Ruda-Kucerova, J.; Salomone, S.; Mechoulam, R.; Drago, F.; Sulcova, A.; Micale, V. Peripubertal treatment with cannabidiol reverses behavioral alterations in ∆9-THC animal model of schizophrenia. European Neuropsychopharmacology 2019, 29 (S1), S257–S258.




Di Bartolomeo, M.; Stark, T.; Pucci, M; Drago, F.; Kuchař, M.; Mauro, M.; Vincenzo, M; Claudio, D. Effects of perinatal cannabis exposure on transcriptional regulation of dopamine receptor d2 and cannabinoid receptor 1 in rats at adulthood. European Neuropsychopharmacology 2019, 29 (S1), S109–S110.




Holubová, B.; Mikšátková, P.; Kuchař, M.; Karamonová, L; Lapčík, O.; Fukal, L.
Immunochemical techniques for anabolic androgenic steroid: matrix effects study for food supplements. European Food Research and Technology 2019, 245, 1011–1019.




Šuláková, A.; Fojtíková, L.; Holubová, B.; Bártová, K.; Lapčík, O.; Kuchař, M. Two immunoassays for the detection of 2C-B and related hallucinogenic phenethylamines. Journal of Pharmacological and Toxicological Methods 2019, 95, 36–46.




Jurásek, B.; Bartůněk, V.; Huber, Š.; Kuchař, M.
X-Ray powder diffraction – A non-destructive and versatile approach for the identification of new psychoactive substances. Talanta 2019, 195, 414–418.




Patents:




Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M.; Holubová, B. Použití derivátu tryptaminu. CZ Patentový spis 307719, Feb 06, 2019.




 
2018
Journal articles:




Jurásek, B.; Králík, F.; Rimpelová, S.; Čejka, J.; Setnička, V.; Ruml, T.; Kuchař, M.; Kohout, M. Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic. New Journal of Chemistry 2018, 42 (24), 19309–20250.




Prochazkova, L.; Lippelt, D.P.; Colzato, L.S.; Kuchar, M.; Sjoerds, Z.; Hommel, B.
Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting. Psychopharmacology  2018, 235, 3401–3413.




Uttl, L.; Szczurowska, E.; Hájková, K.; Horsley, R.R.; Štefková, K.; Hložek, T.; Šichová, K.; Balíková, M.; Kuchař, M.; Micale, V.; Páleníček, T. Behavioral and pharmacokinetic profile of indole-derived synthetic cannabinoids JWH-073 and JWH-210 as compared to the phytocannabinoid ∆9-THC in rats. Frontiers in Neuroscience 2018, 12, article 703.




Jurásek, B.; Babor, M.; Huber, Š.; Kuchař, M. X-ray powder diffraction data for methoxmetamine hydrochloride, C14H20ClNO2. Powder Diffraction 2018, 33 (3), 242–245.





Řezanková, K.; Kohoutová, R.; Kuchař, M.; Král, V.; Řezanka, P. Enantioseparation of Novel Psychoactive Chiral Amines and Their Mixture by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors. Chem. Pap. 2018, 72, 2737–2743.




Křížek, T.; Bursová, M.; Horsley, R.; Kuchař, M.; Tůma, P.; Čabala, R.; Hložek, T. Menthol-Based Hydrophobic Deep Eutectic Solvents: Towards Greener and Efficient Extraction of Phytocannabinoids. J. Clean. Prod. 2018, 193, 391–396.




Horsley, R. R.; Lhotkova, E.; Hajkova, K.; Feriancikova, B.; Himl, M.; Kuchar, M.; Páleníček, T. Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat. Front. Psychiatry 2018, 9, article 144.




Maryška, M.; Fojtíková, L.; Jurok, R.; Holubová, B.; Lapčík, O.; Kuchař, M.; Use of novel haptens in the production of antibodies for the detection of tryptamines. RSC Adv. 2018, 8 (29), 16243–16250.




Sýkorová, S.; Fojtíková, L.; Kuchař, M.; Mikšátková, P.; Karamonová, L.; Fukal, L.; Lapčík, O.; Holubová, B. Sensitive Enzyme Immunoassay for Screening Methandienone in Dietary Supplements. Food Addit. Contam. Part A 2018, 35 (9), 1653–1661.




Králík, F.; Jirmásek, P.; Kuchař, M.; Setnička, V. Chiroptical and Vibrational Spectroscopic Study of Genuine and Counterfeit Medicines Containing Tadalafil. Chirality 2018, 30 (5), 560–567.





Spálovská, D.; Králík, F.; Kohout, M.; Jurásek, B.; Habartová, L.; Kuchař, M.; Setnička, V. Structure Determination of Butylone as a New Psychoactive Substance Using Chiroptical and Vibrational Spectroscopies. Chirality 2018, 30 (5), 548–559.




Šíchová, K.; Pinterová, N.; Židková, M.; Horsley, R. R.; Lhotková, E.; Štefková, K.; Vejmola, Č.; Uttl, L.; Balíková, M.; Kuchař, M.; Páleníček, T. Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats. Front. Psychiatry 2018, 8, article 306.




Jirouskova, M.; Nepomucka, K.; Oyman-Eyrilmez, G.; Kalendova, A.; Havelkova, H.; Sarnova, L.; Chalupsky, K.; Schuster, B.; Benada, O.; Miksatkova, P.; Kuchar, M.; Fabian, O.; Sedlacek, R.; Wiche, G.; Gregor, M. Plectin Controls Biliary Tree Architecture and Stability in Cholestasis. J. Hepatol. 2018, 68 (5), 1006–1017.





Fojtíková, L.; Šuláková, A.; Blažková, M.; Holubová, B.; Kuchař, M.; Mikšátková, P.; Lapčík, O.; Fukal, L. Lateral Flow Immunoassay and Enzyme Linked Immunosorbent Assay as Effective Immunomethods for the Detection of Synthetic Cannabinoid JWH-200 Based on the Newly Synthesized Hapten. Toxicol. Reports 2018, 5, 65–75.





2017
Journal articles:




Jurasek, B.; Himl, M.; Jurok, R.; Hajkova, K.; Vobinuskova, A.; Rezanka, P.; Kuchar, M. Synthesis of Methoxetamine, Its Metabolites and Deuterium Labelled Analog as Analytical Standards and Their HPLC and Chiral Capillary Electrophoresis Separation. RSC Adv. 2017, 7 (89), 56691–56696.




Štefková, K.; Židková, M.; Horsley, R. R.; Pinterová, N.; Šíchová, K.; Uttl, L.; Balíková, M.; Danda, H.; Kuchař, M.; Páleníček, T. Pharmacokinetic, Ambulatory, and Hyperthermic Effects of 3,4-Methylenedioxy-N-Methylcathinone (Methylone) in Rats. Frontiers in Psychiatry 2017, 8, article 232.




Hložek, T.; Uttl, L.; Kadeřábek, L.; Balíková, M.; Lhotková, E.; Horsley, R. R.; Nováková, P.; Šíchová, K.; Štefková, K.; Tylš, F.; Kuchař, M.; Páleníček, T.  Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC. European Neuropsychopharmacology 2017, 27 (12), 1223–1237.




Maixner, J.; Jurásek, B.; Himl, M.; Kuchař, M.; Babor, M. X-Ray Powder Diffraction Data for Methoxetamine Hydrochloride, C15H22ClNO2. Powder Diffraction 2017, 32 (4), 265–267.




Maixner, J.; Jurásek, B.; Kohout, M.; Kuchař, M.; Kačer, P. X-ray powder diffraction data for (S)-Deschloroketamine hydrochloride, C13H18ClNO. Powder Diffraction 2017, 32 (3), 193–195.




Fagan, P.; Kocourková, L.; Tatarkovic, M.; Králík, F.; Kuchař, M.; Setnička, V.; Bouř, P. Cocaine Hydrochloride Structure in Solution Revealed by Three Chiroptical Methods. ChemPhysChem 2017, 18 (16), 2258–2265.





Fojtíková, L.; Holubová, B.; Kuchař, M. New psychoactive substances. Chemické listy 2017, 111 (4), 234–238.




Androvicová, R.; Horáček, J.; Tintěra, J.; Rýdlo, J.; Jezová, D.; Balíková, M.; Hložek, T.; Mikšátková, P.; Kuchař, M.; Hlinka, J.; Roman, M. Acute Cannabis Intoxication and the Brain's Response to Visual Erotica: An Fmri Study. The Journal of Sexual Medicine 2017, 14 (5), e253. DOI: 10.1016/j.jsxm.2017.04.250.




Androvicova, R.; Horáček, J.; Tintěra, J.; Hlinka, J.; Rydlo, J. Ježová, D.; Balíková, M.; Hložek, T.; Mikšátková, P.; Kuchař, M.; Roman, M.; Tomíček, P.; Tylš, F.; Viktorinová, M.; Páleníček, T. Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study. Psychopharmacology  2017, 243 (13), 1933.




Kolderová, N.; Neveselý, T.; Šturala, J.; Kuchař, M.; Holakovský, R.; Kohout, M. Enantioseparation of Chiral Sulfoxides on Amylose-Based Columns: Comparison of Normal Phase Liquid Chromatography and Supercritical Fluid Chromatography. Chromatographia 2017, 80 (4), 547–557.




Kučerová, S.; Kuchař, M. Průzkum zneužívání omamných a psychotropních látek u klientů centra substituční léčby. Drugs and Forensics Bulletin 2017, 1, 16–25.




Patents:




Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Holubová, B. Derivát syntetického kanabinoidu, způsob přípravy a použití. CZ Patentový spis 306547, 2017.




 
2016
Journal articles:




Bartůněk, V.; Huber, Š.; Luxa, J.; Sofer, Z.; Kuchař, M.; Dobrovolný, K. Facile Synthesis of Magnetic Cobalt Nano-foam by Low-temperature Thermal Decomposition of Cobalt Glycerolate. Micro & Nano Letters 2017, 12 (5), 278–280.




Nemeškalová, A.; Kuchař, M. Přírodní a syntetické opiáty. Drugs and Forensics Bulletin 2016, 4, 11–17.




Bartůněk, V.; Rak, J.; Pelánková, B.; Junková, J.; Mezlíková, M.; Král, V.; Kuchař, M.; Engstová, H.; Ježek, P.; Šmucler, R. Large scale preparation of up- converting YF3: YbEr nanocrystals with various sizes by solvothermal syntheses using ionic liquid bmimCl. Journal of fluorine chemistry 2016, 188, 14–17.




Gotvaldová, K.; Kuchař, M. Lysohlávky - Halucinogenní houby z rodu Psilocybe. Drugs and Forensics Bulletin 2016, 3, 8–14.




Lehmert, K.; Šťastná, P.; Kuchař, M.; Hájková, K. Dopady nelegální varny metamfetaminu na lidské zdraví a životní prostředí. Drugs and Forensics Bulletin 2016, 3, 15–21.




Bartůněk, V.; Dobrovolný, K.; Švecová, M.; Matějka, P.; Šída, P.; Pokorný, P.; Kuchař, M.; Černá, E. Obtaining Black Carbon—A Simple Method for the Safe Removal of Mineral Components from Soils and Archaeological Layers. Archaeometry, 2017, 59 (2), 346–355.




Krysova, H.; Bartoň, J.; Petrák, V.; Jurok, R.; Kuchař, M.; Cígler, P.; Kavan, L. Efficiency and Stability of Spectral Sensitization of Boron-Doped-Diamond Electrode through Covalent Anchoring of a Donor-Acceptor Organic Chromophore (P1). Phys Chem Chem Phys 2016, 18, 16444–16450.




Jurášek, M.; Göselová, S.; Mikšátková, P.; Holubová, B.; Vyšatová, E.; Kuchař, M.; Fukal, L.; Lapčík, O.; Drašar, P. Highly sensitive avidin-biotin ELISA for detection of nandrolone and testosterone in dietary supplements. Drug Test Anal, 2017, 9 (4), 553–560.




Hegrová, M.; Řezanková, K.; Kuchař, M.; Řezanka, P. Separace enantiomerů kathinonů kapilární elektroforézou s využitím cyklodextrinů jako chirálních selektorů. Chemické listy 2016, 110, 200–203.




Pamánková, P.; Kuchař, M. Analýza a využití konopí v medicíně. Drugs and Forensics Bulletin 2016, 2, 29–39.




Horsley, R. R.; Lhotkova, E.; Hajkova, K.; Jurasek, B.; Kuchar, M.; Palenicek, T. Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue—Behavioural, pharmacokinetic and metabolic studies in the Wistar rat. Brain Res Bull 2016, 126 Part 1, 102–110.




Fojtíková, L.; Fukal, L.; Blažková, M.; Sýkorová, S.; Kuchař, M.; Mikšátková, P.; Lapčík, O.; Holubová, B. Development of enzyme-linked immunosorbent assay for determination of boldenone in dietary supplements. Food Anal Method 2016, 9 (11), 3179–3186.




Páleníček, T.; Lhotková, E.; Žídková, M.; Balíková, M.; Kuchař, M.; Himl, M.; Mikšátková, P.; Čegan, M.; Valeš, K.; Tylš, F.; Horsley, R. R. Emerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and LD50 in rats. Prog Neuropsychopharmacol Biol Psychiatry 2016, 69 (1), 49–59.




Jurásek, B.; Kuchař, M. Methoxetamine. Drugs and Forensics Bulletin  2016, 1, 27–31.




Bartůněk, V.; Junková, J.; Babuněk, M.; Ulbrich, P.; Kuchař, M.; Sofer, Z. Synthesis of spherical amorphous selenium nano and microparticles with tunable sizes. Micro Nano Lett 2016, 11 (2), 91–93.




Wolrab, D.; Frühauf, P.; Moulisová, A.; Kuchař, M.; Gerner, C.; Lindner, W.; Kohout, M.; Chiral separation of new designer drugs (Cathinones) on chiral ion-exchange type stationary phases. J Pharm Biomed Anal 2016, 120, 306–315.




Hájková, K.; Jurásek, B.; Sýkora, D.; Páleníček, T.; Mikšátková, P.; Kuchař, M. Salting-out assisted liquid-liquid extraction as a suitable approach for determination of methoxetamin in large sets of tissue samples. Anal Bioanal Chem 2016, 408 (4), 1171–1181.




Patents:




Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O. Derivát syntetického kanabinoidu, způsob jeho přípravy a využití. CZ Patentový spis 305780, 2016.




Function samples:




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči- dimethyltryptamin (DMT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - dimethyltryptamin (DMT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči - 5-methoxy-N,N-dimethyltryptamin (5-MeO-DMT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 5-methoxy-N,N-dimethyltryptamin (5-MeO-DMT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - JWH-200 (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - diisopropyltryptamin (DiPT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči- diisopropyltryptamin (DiPT) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 4-brom-2,5-dimethoxyfenylethylamin (2-CB) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči - 4-brom-2,5-dimethoxyfenylethylamin (2-CB) (příbalový leták)




Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 5-jod-2-aminoindan (5-IAI) (příbalový leták)




Conference proceedings:




Kuchař, M. Nové syntetické drogy a jejich možná rizika.  Snižování škod a drogy, Snižování škod a drogy; Hanková, O., Ed.; 2016; pp 83–88.





2015
Journal articles:




Bartůněk, V.; Pinca, J.; Ulbrich, P.; Rak, J.; Pelánková, B.; Král, V.; Kuchař, M.; Ježek, P.; Engstová, H.; Smolková, K. Tunable rapid microwave synthesis of up-converting hexagonal NaYxGdyYbzEr(1−x−y−z)F4 nanocrystals in large quantity. J. Fluorine Chem. 2015, 178, 56–60.




Prokudina, E. A.; Prchalová, J.; Vyšatová, E.; Kuchař, M.; Rajchl, A.; Lapčík, O. Analysis of anabolic androgenic steroids by direct analysis in real time ionization with time-of-flight mass spectrometry. International Journal of Mass Spectrometry 2015, 392, 28–33.




Hrachovec, M.; Franěk, L.; Kuchař, M. Nelegální výroba heroinu z přípravku Vendal retard. Bulletin Národní protidrogová centrála 2015, 3, 3-6.




Hrachovec, M.; Kuchař, M. Červený fosfor – klíčová substance při výrobě metamfetaminu. Bulletin Národní protidrogová centrála 2015, 3, 16-20.




Mikšátková, P.; Kuchař, M. Zdravotní rizika užívání anabolických steroidů. Bulletin Národní protidrogová centrála 2015, 3, 21-26.




Kuchař, M. Aktuální případy intoxikací v Polsku po užití NPS. Bulletin Národní protidrogová centrála 2015, 3, 38-39.




Švejcarová, S.; Sýkora, D.; Kuchař, M. Stanovení extrakčního výtěžku pseudoefedrinu z léčivých přípravků. Bulletin Národní protidrogová centrála 2015, 4, v tisku




Patents:




Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M. Imunochromatografický test dimethyltryptaminových drog. Užitný vzor CZ 28938 U1, Dec 07, 2015.




Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M. Imunochromatografický test syntetických kanabinoidů. Užitný vzor CZ 28908 U1, Nov 30, 2015.




Conference proceedings:




Šuláková A., Fojtíková L., Kuchař M., Lapčík O.: Development of User Friendly Test for Synthetic Cannabinoid JWH200. The 13-th International Kyoto Conference on New Aspects of Organic Chemistry.Pragram and Abstracts II. Poster PC(D)29, p. 189.  Kyoto, November 9-13, 2015.




Kuchař M., Roman M.: Analýza psychoaktivních látek ve vlasech, konference Trestně právní a kriminalistické aspekty dokazování, str. 98-109, Praha 13.3.2015, ISBN 978-80-7408-112-5




Book chapters and software:




Kuchař, M. Nové psychoaktivní látky. In Klinická adiktologie, 1st ed.; Kalina, K.; et al. Grada Publishing, a.s: Příbram, 2015; pp 84–95.




Kuchař, M.; Hořínek, J.; Svozil, D.; Čermák, J. Database of new synthetic drugs. (RIV/60461373:22310/13:43896676)




Legislation:




Kuchař, M.; Novák, P.; Polansky, P.; Rinke, J.; Hrachovec, M. Nařízení vlády č. 243/2015 o seznamech návykových látek.




Kuchař, M.; Novák, P.; Polansky, P.; Rinke, J.; Hrachovec, M. Nařízení vlády č. 242/2015 o seznamu výchozích a pomocných látek a jejich ročních množstevních limitech návykových látek.





by 2015
Journal articles:




Kuchař, M.; Kitzlerova, A. Nové zneužívané látky v Evropě/ New misused substances in Europe. Bulletin National Drug Headquartes 2014, 4, 3-9.




Lehmert, K.; Kuchař, M. CBRNe: Bilý prášek – droga, jed nebo cukr?/ CBRNe: White powder – drugs, poison or sugar?. Bulletin National Drug Headquartes 2014, 3, 23-28.




Kuchař, M.; Teplárek, P. Likvidace ilegálních laboratoří sloužících k výrobě metamfetaminu/ Dismatling of clandestine methamphetamine laboratory. Bulletin National Drug Headquartes 2014, 1, 9-13.




Bartůněk, V.; Rak, J.; Pelánková, B.; Sofer, Z.; Ulbrich, P.; Kuchař, M.; Král, V. Preparation and luminescent properties of cubic potassium-erbium fluoride nanoparticles. J Fluorine Chem 2013, 156, 363–366.




Kuchař, M.; Teplárek, P. EU – China Trade Project. Bulletin National Drug Headquartes 2013, 1, 20-21.




Kuchař, M. Nové syntetické drogy – review/New synthetic drugs – review. Bulletin National Drug Headquartes 2012, 4, 25-28.




Kuchař, M. Pré-prekursory drog – nové trendy v Evropské Unii/Pré-precursors – new trends in European Union. Bulletin National Drug Headquartes 2012, 4, 3-5.




Páleníček, T.; Kuchař, M. Je možná identifikace nových syntetických drog (NSD) pomocí orientačních testů?/Can Rapid Tests Be Used to Detect and Identify New Synthetic Drugs (NSDs)? Addictology 2011, 11(4), 208-214.




Vaněček, M.; Kuchař, M. Fentanyl/Fentanyl. Bulletin National Drug Headquartes 2011, 4, 3-4.




Hrachovec, M.; Kuchař, M. Nebezpečné chemikálie a Pyromeeting 2011/Dangerous Chemicals and Pyromeeting 2011. Bulletin National Drug Headquartes 2011, 3, 18-21.




Tomíček, P.; Kuchař, M. Cvičení Peaceful-Dragon/Training Peaceful Dragon. Bulletin National Drug Headquartes 2011, 3, 14-17.




Kuchař, M. „Mephedron, droga roku 2010/Mephedrone, drugs of the year 2010“. Bulletin National Drug Headquartes 2010, 3, 36-37.




Kuchař, M. Příměsi v nelegálních drogách – identifikace a jejich profil/Cutting agents in illicit drugs. Bulletin National Drug Headquartes 2010, 2, 43-44.




Conference proceedings:




Goselova, S.; Holubova, M.; Blazkova, M.; Jurok, R.; Huml, L.; Kuchar, M.; Lapcik, O.; Fukal, L. The development of a sensitive immunoassay for the detection of new synthetic drugs, SW05.S23–18 The FEBS Journal 2013, 280 (2).




Legislation:




Kuchař, M.; Ondroušková, A.; Novák, P.; Polansky, P.; Roman, M. Nařízení vlády č. 463/2013 o seznamech návykových látek.




Kuchař, M.; Ondroušková, A.; Novák, P.; Hrachovec, M. Nařízení vlády č. 458/2013 o seznamu výchozích a pomocných látek a jejich ročních množstevních limitech.




Kuchař, M.; Ondroušková, A.; Hlásenský, I.; Novák, P.; Polansky, P.; Hrachovec, M. Zákon č. 272/2013 Sb. o prekurzorech drog.




Kuchař, M.; Ondroušková, A.; Novák, P.; Roman, M. Zákon č. 106/2011 Sb., kterým se mění zákon č. 167/1998 Sb., o návykových látkách a o změně některých dalších zákonů, ve znění pozdějších předpisů.




 
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Ongoing projects:

Development of a receptor biochip for the control and regulation of steroid hormones (FW06010206)

Years: 2023 – 2026
Principal investigator: ESSENCE LINE, s.r.o.
Co-investigators: UCT Prague, NIMH Klecany



New psychoactive substances: forensic-toxicology research center (VK01010212)

Years: 2023 – 2026
Principal investigator: UCT Prague
Co-investigator: NIMH Klecany, Police Academy of the Czech Republic


Field quantification of narcotic and psychotropic substances using NIR spectrometry (VK01010137)

Years: 2023 – 2026
Principal investigator: UCT Prague


Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression (NU21-04-00307)

Years: 2021 – 2024
Principal investigator: NIMH Klecany
Co-investigators: UCT Prague


Express and portative detection of prohibited substances using innovative techniques: flexible and chiral SERS, selective surface extraction, artificial neural networks. (VJ01010065)

Years: 2021 – 2025
Principal investigator: UCT Prague


Pharmacrime – forensic identification of prohormones and counterfeid medicine (VJ01010043)

Years: 2021 – 2025
Principal investigator: UCT Prague
Co-investigators: Ministry of Interior of the Czech Republic


Minimalizace vlivu residuální kontaminace po nelegální výrobě narkotik na zdraví člověka (MPO/FV30483)

Doba řešení: 2018 – 2021
Spoluřešitel: Ing. Martin Kuchař, Ph.D.


New synthetic drugs- complex interdisciplinar research center (MV0/VI20172020056)

Years: 2017 – 2020
Principal investigator: doc. Ing. Martin Kuchař, Ph.D.


Development of new methods and tools for the detection and investigation of cases of drug counterfeits for better protection of society (MV0/VI20152020048)

Years: 2015 – 2020
Principal investigator: doc. Ing. Martin Kuchař, Ph.D.


Minimizing the impact of residual contamination after illicit narcotics production on human health (MPO/FV30483)

Years: 2018 – 2021
Co-investigator: doc. Ing. Martin Kuchař, Ph.D.


Ongoing student IGA grants (University research grants):
2023
Study of degradation of endocrine disruptors in aqueous environment using photocatalysts immobilized by the airbrush method (A2_FPBT_2023_031)

Hlavní řešitel: Ing. Barbora Walderová (Mužíková)



Finished grants I
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AbSciex 6500+ QTRAP + 2D UHPLC



 
 
 
 
AbSciex 6500+ QTRAP + 2D UHPLC was funded from research grant MV0/VI20152020048 (2015 - 2020, principal investigator: Ing. Martin Kuchař, Ph.D.)
Contact: Ing. Kateřina Hájková




Preparative LC Waters AutoPurificationTM, Acquity UtraPerformance Convergence Chromatography (UPC2)



 
 
 
 
  
Preparative LC Waters AutoPurificationTM, Acquity UtraPerformance Convergence Chromatography (UPC2) was funded from research grant OP VaVpI 1.05/4.1.00/16.0349
Contact: Ing. Michal Kohout, Ph.D.




UHPLC/MS system Agilent, 6460 triple quadrupole and 1290 Infinity LC




 
 
 
 
UHPLC/MS system Agilent, 6460 triple quadrupole and 1290 Infinity LC, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant CRP C26 (principal investigator: prof. Ing. Zdeněk Wimmer, DrSc.) and co-funded from funds of the Department of Chemistry of Natural Compounds.
Contact: Ing. Elena Prokudina, Ph.D.; Prof. Dr. RNDr. Oldřich Lapčík.




CombiFlash® Rf 200



  
 
 
 
Automatic flash chromatography system CombiFlash Rf-200, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant MV0/VG20122015075 (2012 - 2015, principal investigator: prof. Dr. RNDr. Oldřich Lapčík)
Contact:  Prof. Dr. RNDr. Oldřich Lapčík.




UHPLC/MS system Agilent,  6550 iFunnel Q-TOF and Infinity 1290 LC



 
 
 
 
 
UHPLC/MS system Agilent,  6550 iFunnel Q-TOF and Infinity 1290 LC, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant OP VaVpI 1.05/4.1.00/16.0349 with financial support from funds of the Department of Chemistry of Natural Compounds.
Contact: Ing. Elena Prokudina, Ph.D.; Prof. Dr. RNDr. Oldřich Lapčík.




 
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Internal collaborations at UCT Prague


Department od analytical chemistry

Chiroptical methods group, Vibrational spectroskopy group - prof. Ing. Vladimír Setnička, Ph.D.
Separation methods group -  doc. Dr. RNDr. David Sýkora

Department of informatics and chemistry

Chemoinformatics group - doc. Mgr. Daniel Svozil, Ph.D.

Department of chemistry of natural compounds

Analytical and bioanalytical methods group - prof. Dr. RNDr. Oldřich Lapčík

Department of biochemistry and microbiology

Laboratory of bioaffinity techniques - prof. Ing. Ladislav Fukal, CSc.
Laboratory of metalomics a bioremediation of heavy metals - doc. Ing. Pavel Kotrba, Ph.D.
Laboratory of molecular biology a virology - prof. Ing. Tomáš Ruml, CSc.

 
External collaborations




National institute of mental health - NIMH


MUDr. Tomáš Páleníček, Ph.D.; prof. MUDr. Jiří Horáček, Ph.D.; Ing. Jakub Rak, Ph.D.; RNDr. Karel Valeš, Ph.D.
Involvement, inter alia, within the ERDF/ESF project PharmaBrain (CZ.02.1.01/0.0/0.0/16_025/0007444)






Institute of Macromolecular Chemistry, Czech Academy of Sciences


Department of supramolecular polymer systems - Mgr. Martin Hrubý, DSc.






Centre of the Region Haná for Biotechnological and Agricultural Research - Palacký University


Oddělení fytochemie UP - doc. RNDr. Petr Tarkowski, Ph.D.






Institute of Chemical Process Fundamentals, Czech Academy of Sciences


Department of Advanced Materials and Organic Synthesis - Ing. Jan Štorch, Ph.D.






University of Amsterdam


Religion Cognition and Behavior Lab - dhr. dr. Michiel van Elk






Copenhagen university hospital


Neurobiology Research Unit






University of Catania


Department of Biomedical and Biotechnological Sciences - doc. Vincenzo Micale

 





National Monitoring Centre for Drugs and Addiction, Office of the Government of the Czech Republic 


MUDr. Viktor Mravčík, Ph.D.






Institute of Forensic Medicine and Toxicology, 1st Faculty of Medicine, Charles University


National reference laboratory for forensic toxicology - doc. Ing. Marie Balíková

 





Department of Pharmacology, 3rd Faculty of Medicine, Charles University


PharmDr. Magda Šustková, CSc.

 





Police of the Czech Republic – Forensic Institute Prague
 





Czech agriculture and food inspection authority
 





European Monitoring Centre for Drugs and Drug Addiction – EMCDDA





Czech olympic committee





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Základní údaje o škole 
The laboratory is located on the first floor of building B. 
Map - work place of the laboratory

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DATA

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Employees


 
Students


 
Alumni




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    [platne_od] => 26.02.2023 18:19:00
    [zmeneno_cas] => 26.02.2023 18:20:05.063673
    [zmeneno_uzivatel_jmeno] => Natalie Paškanová
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Head of the laboratory:





doc. Ing. Martin Kuchař, Ph.D.
   UCT building B, room 129
    +420 22044 4431
    Martin.Kuchar[at]vscht.cz


CV
ResearchGate




Head of organic division:





Ing. Radek Jurok, Ph.D.
   UCT building B, room 129
    +420 22044 4430
   Radek.Jurok[at]vscht.cz







Head of analytical division:





PharmDr. Petra Cihlářová, Ph.D.
   UCT building B, room 129
    +420 22044 4430
    Petra.Cihlarova[at]vscht.cz







Administrative support:





Ing. Patricie Kosmatová
(maternity leave)

   UCT building B, room 129
    +420 22044 4431
    Patricie.Kosmatova[at]vscht.cz








Ing. Šimon Šuda
    UCT building B, Z B3-208
     +420 22044 4484
    Simon.Suda[at]vscht.cz







Technician:





Eliška Janebová
   UCT building B, room 129
    +420 22044 4431
   Eliska.Janebova[at]vscht.cz








Bc. Petr Palivec
   UCT building B, room 129
    +420 22044 4431
   palivecp[at]vscht.cz







Other employees:





Ing. Bronislav Jurásek, Ph.D.
   UCT building B, room 129
    +420 22044 4432
   jurasekb[at]vscht.cz








RNDr. Lucie Janečková, Ph.D.
   UCT building B, room 129
    +420 22044 4431
    Lucie.Janeckova[at]vscht.cz








Ing. Johanna Kozánková
   UCT building B, room 129
    +420 22044 4431
    kozankoj[at]vscht.cz


















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Ph.D. students:






Mgr. Monika Mrňavá
b mrnavam[at]vscht.cz
Thesis: Utilization of liquid chromatography-mass spectrometry for the metabolic study of psychoactive substances
Supervisor: doc. Martin Kuchař, Ph.D.




CV
LinkedIn







Ing. Petr Palivec
b palivecp[at]vscht.cz
Thesis: Synthesis of metabolites and their isotopically labeled analogues for the biotransformation study of psychoactive substances
Supervisor: doc. Martin Kuchař, Ph.D.













Ing. Kateřina Knížková
b knizkovk[at]vscht.cz
Thesis: Study of the contents of plant adaptogens
Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: PharmDr. Petra Cihlářová, Ph.D.











 


Ing. Magdaléna Vágnerová
b vagnerom[at]vscht.cz
Thesis: Study of pharmacokinetics and metabolism of psychoactive compounds by LC-MS
Supervisor: doc. Dr. RNDr. David Sýkora
Consultant: doc. Martin Kuchař, Ph.D.


ReseachGate







Ing. Tereza Maříková
b marikovt[at]vscht.cz
Thesis: Development of analytical methods for the study of photocatalytic degradation of organic pollutants from wastewater
Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: Ing. Jiří Rathouský, Csc.













Ing. Walderová Barbora (Mužíková)
b muzikovb[at]vscht.cz
Thesis: Photocatalytic degradation of new types of organic pollutants in wastewater

Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: Ing. Jiří Rathouský, Csc.



CV






Ing. Hana Walaská
b walaskah[at]vscht.cz
Thesis: Study of new psychoactive substances as potential neuro pharmaceutics
Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: -



CV








Ing. Natalie Paškanová
b kolderon[at]vscht.cz
Thesis: Chiral separation of new psychoactive substances using supercritical fluid chromatography coupled to mass spectrometry
Supervisor: Ing. Martin Kuchař, Ph.D.
Consultant: doc. Ing. Michal Kohout, Ph.D.


ResearchGate




 
Master students:






Bc. Jáchym Fibír


Supervisor: Ing. Radek Jurok, Ph.D.







Bc. Hedvika Češková

Supervisor: Ing. Martin Kuchař, Ph.D.
Consultant: Ing. Bronislav Jurásek




 
Bachelor students:





Šejla Musić


Thesis: Analýza vybraných syntetických kanabinoidů a metamfetaminu metodou hmotnostní spektrometrie
Supervisor: Ing. Martin Kuchař, Ph.D.
Consultant: Mgr. Edita Kofroňová, Ph.D.





Vojtěch Suchopár

Supervisor: Ing. Radek Jurok, Ph.D.





Eliška Smolová

Supervisor: Ing. Radek Jurok, Ph.D.






Domink Friml

Supervisor: Ing. Martin Kuchař, Ph.D.
Consultant: Ing. Magdaléna Vágnerová









 





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Ing. Walderová Barbora (Mužíková)
b muzikovb[at]vscht.cz
Thesis: Photocatalytic degradation of new types of organic pollutants in wastewater

Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: Ing. Jiří Rathouský, Csc.



      





Education

2020-present 
UCT Prague
Ph.D. candidate, program Biochemistry and bioorganic chemistry
Thesis topic: Photocatalytic degradation of new types of organic pollutants in wastewater (supervisor doc. Martin Kuchař)

2018-2020 
UCT Prague
Graduate program Forensic Analysis (FORCH)
Thesis topic: Identification and quantification of bioactive components in samples of narcotic and psychotropic substances by NMR (supervisor doc. Bohumil Dolenský)

2015-2018 
UCT Prague
Undergraduate program Forensic Analysis (FA)
Thesis topic: Identification of new psychoactive substances by NMR (supervisor doc. Martin Kuchař) 



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Ing. Hana Walaská
b walaskah[at]vscht.cz
Thesis: Study of new psychoactive substances as potential neuro pharmaceutics
Supervisor: doc. Martin Kuchař, Ph.D.
Consultant: -










Education
2015-2018
 Bachelor's studies in Drug Synthesis and Production, Faculty of Chemical Technology UCT Prague
 
2018-2020 
Master's studies in Biomaterials, Faculty of Chemical Technology UCT Prague
 
Both Bachelor's and Diploma thesis under the supervision of doc. Oleksiy Lyutakov (Department of Solid State Engineering, UCT Prague) and dr. Jaroslav Žádný (GAMOS, Institute of Chemical Process Fundamentals of the CAS)

 
2021-now
 PhD studies in Biochemistry and Bioorganic chemistry, Department of Chemistry of Natural Compounds, supervised by doc. Martin Kuchař, dissertation topic: Study of new psychoactive substances as potential neuro pharmaceutics
 
Teaching 
B143001 Chemical Informatics - seminars

 
Professional interest

Organic synthesis and study of new psychoactive compounds
Study of natural psychoactive compounds and their isolation from plants
 
Other professional activities
2021-now 
External consultant for toxic substances at Arnika NGO
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Mgr. Monika Mrňavá
b mrnavam[at]vscht.cz
Thesis: Utilization of liquid chromatography-mass spectrometry for the metabolic study of psychoactive substances
Supervisor: doc. Martin Kuchař, Ph.D.




LinkedIn







Education

2023- until now
Biochemistry and Bioorganic chemistry
Faculty of Food and Biochemical Technology
Doctoral
University of Chemistry and Technology, Prague

2022
Internship
Centro Regionale Antidoping "Alessandro Bertinaria"
Analysis of novel psychoactive substances in hair samples with use of UHPLC-HRMS-QTOF
Turin, Piemonte, Italy

2021
Erasmus+, trainee in the Ruđer Bošković Institute
Studying abroad as part of the Erasmus+ project with work in a bioanalytical laboratory within the subject: introduction to proteomics
The University of Zagreb, Croatia

2020-2023
Chemistry - spec. Toxicology and analysis of pollutants
Master's degree
University of Hradec Kralove

2017-2020
Chemistry - spec. Toxicology and analysis of pollutants
Bachelor's degree
University of Hradec Kralove
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2022




Mgr. Alžběta Nemeškalová, Ph.D.
 Utilization of liquid chromatography-mass spectrometry for the analysis of psychoactive substances in unconventional matrices. (Dissertation)




Ing. Michal Maryška, Ph.D.
Synthesis of compounds affecting the tryptophan metabolic pathway and serotonin system. (Dissertation)




Ing. Kristýna Fedorová
Chiral separation of inherently chiral macrocyclic receptors. (Master thesis)




Ing. Kateřina Obytová
Determination of CBD and its metabolites in rat serum by HPLC-MS. (Master thesis)




Ing. Kateřina Knížková
Determination of bioactive compounds in maral root (Rhaponticum carthamoides). (Master thesis)




Ing. Kristýna Krunclová
The analysis of metabolites of a psychoactive compound ibogaine via LC-MS. (Master thesis)




2021




Ing. Kateřina Hájková, Ph.D.
The analysis of psychoactive compounds and their metabolites by LC-MS. (Dissertation)




Ing. Bronislav Jurásek, Ph.D.
Analogs and Metabolites of New Psychoactive Substances. (Dissertation)




Ing. Magdaléna Vágnerová
Quantitative analysis of selected cannabinoids in cannabidiol-rich cosmetic products. (Master thesis)





Ing. Tereza Maříková
Preparative enantioseparation of psychoactive substances.  (Diplomová práce)




Ing. Daniela Brdová
Pharmacokinetics study of baeocystin alkaloid and its metabolite norpsilocin by HPLC/MS.  (Master thesis)




Ing. Lucie Pejšková
Mechanism of the influence of cannabinoid receptor CB1 by protein SGIP1. (Master thesis)




Ing. Darya Danilova
Analysis of counterfeit medicine from the benzodiazepine group by HPLC/MS method. (Master thesis)




Ing. Kristýna Hubátková
Development of an immunochromatographic test for the detection of THC. (Master thesis)




Ing. Angelina Beata Pelc
Development of methodology for detection of synthetic cannabinoids using advanced vibrational spectroscopic techniques. (Master thesis)




Ing. Denisa Adamcová
Development of the methodology of transdermal and transcorneal transfer of cannabinoids using advanced vibrational spectroscopic techniques. (Master thesis)




Ing. Lucie Svobodová
Synthesis of thiazole derivatives of α-aminoketones as potential inhibitors of KAT II. (Master thesis)




Ing. Leona Palbuchtová
SDetermination of new types of doping substances by HPLC / MS. (Master thesis)




Ing. Eva Pospíšilová
Electrochemical sensor systems for monitoring of drugs from a group of synthetic cathinones. (Master thesis)




Bc. Michaela Zelená
Analysis of selected anabolic steroids by LC-MS. (Bachelor thesis)




Bc. Vít Lichtenberg
Analysis of phosphodiesterase 5 inhibitors in pharmaceutical preparations by XRPD. (Bachelor thesis)




Bc. Daniel Maxa
Analysis of methylendioxymethamphetamine (MDMA) type tablets by XRPD. (Bachelor thesis)




Bc. Petra Hlavatá
Chiral separation of new psychoactive substances using supercritical fluid chromatography. (Bachelor thesis)




Bc. Kamila Sokolíková
Pharmacokinetic study of psychoactive substance 25CN-NBOMe by HPLC-MS. (Bachelor thesis)




Bc. Kateřina Nováková
Determination of opium alkaloids in commercionally available products by LC-MS method. (Bachelor thesis)




Bc. Adéla Provazníková
The study of transdermal transport of cannabinoids by advanced vibrational spectroscopy techniques. (Bachelor thesis)




Bc. Lukáš Dvořák
Synthesis of isotopically labelled phytocannabinoids. (Bachelor thesis)




Bc. Petr Palivec
Synthesis of metabolites of the new synthetic drug 25CN-NBOMe. (Bachelor thesis)




Bc. Julie Jindrová
Determination of cannabidiol in oil matrix by LC-UV method. (Bachelor thesis)




Bc. Marina Gončarova
Plasmon-assisted chemistry through molecular hot spots. (Bachelor thesis)




Bc. Adriana Valentová
Development of an LC/MS method for the analysis of oil matrices in counterfeit pharmaceuticals. (Bachelor thesis)




2020




Ing. Barbora Mužíková

Identification and quantification of bioactive components in samples of narcotic and psychotropic substances by NMR. (Master thesis)



Ing. Lucie Chaloupková
Identification of metabolites of N-methoxybenzyl derivatives of 2C phenethylamines in the urine by HPLC/MS method. (Master thesis)




Ing. Andrea Pavlíková

Quantitative analysis of selected fytocannabinoid in commercially available cannabis product. (Master thesis)




Ing. Petra Nováková

HPLC-MS quantitative analysis of endogenous steroids in capillary blood. (Master thesis)




Ing. Daniel Heblík

Identification of metabolites of 5-methoxy-dimethyltryptamine by HPLC/MS method. (Master thesis)




Ing. Darya Danilova
Analysis of counterfeit medicine from the benzodiazepine group by HPLC/MS method. (Master thesis)




Bc. Kristýna Fedorová
Pharmacokinetics study of psychoactive compound 2CB-Fly-NBOMe by HPLC/MS. (Bachelor thesis)




Bc. Tomáš Lazák
Analysis of cocaine and its adulterants by XRPD. (Bachelor thesis)




Bc. Alžběta Martincová
Analysis of heroin and its adulterants by XRPD. (Bachelor thesis)




Bc. Kateřina Obytová
Analysis of cannabigerol in biological matrixes by HPLC/DAD/MS. (Bachelor thesis)




Bc. Hedvika Češková
Synthesis of selected metabolites of new psychoactive substance 2CB-Fly-NBOMe. (Bachelor thesis)




Bc. Kateřina Knížková
Analysis of estradiol in serum by HPLC/MS. (Bachelor thesis)




Bc. Kristián Kapusta
Synthesis of fentanyl analogues. (Bachelor thesis)




2019




Ing. Anna Šuláková, Ph.D.
Immunoreactive derivatives of new synthetic drugs. (Dissertation)



Ing. Natalie Kolderová
Chiral separation of deschloroketamine and its metabolites in biological matrixes using supercritical fluid chromatography. (Masters thesis)



Ing. Lenka Vatrsková
Potentiometric studies between calix[4arene acetate and cathinones. (Masters thesis)



Bc. Daniela Brdová
Determination of brominated cannabidiol in biological matrix by LC-MS. (Bachelor thesis)



Bc. Angelika Beata Pelc
Identification of synthetic cannabinoids by Raman and infrared spectroscopy. (Bachelor thesis)



Bc. Leona Palbuchtová
Analysis of selected endogenous steroids in biological matrices by HPLC-MS. (Bachelor thesis)



Bc. Lucie Škuderová
Synthesis of analytical standards for the profiling of 4-fluoroamphetamine. (Bachelor thesis)



Bc. Anna Jelínková
Synthesis of synthetic stimulants derived from 5-(2-aminopropyl)benzofuran. (Bachelor thesis)



Bc. Ivana Belaňová
Analysis of amphetamine type stimulants in meconium samples. (Bachelor thesis)



Bc. Karolína Kubíčková
Analysis of cocaine and cutting agents by NMR. (Bachelor thesis)



Bc. Adéla Loukotová
Detection of cocaine cutting agents by vibrational spectroscopy. (Bachelor thesis)



 
2018




Ing. Šárka Bicanová
Development of LC-MS method for the determination of cannabinoids in transdermal transport. (Masters thesis)



Ing. Klára Gotvaldová
HPLC-MS quantitative analysis of tryptamine alkaloids in Basidiomycetes fungi. (Masters thesis)



Ing. David Mervart
Pharmacokinetic study of synthetic cannabinoids by HPLC-MS method. (Masters thesis)



Ing. Pavla Průchová
Quantitative analysis of endogenous steroids in human serum under the clinical trial of the plant Tribulus terrestris by HPLC-MS. (Masters thesis)



Bc. Jáchym Fibír
Synthesis of Cannabidiol and Cannabidiolic Acid Derivatives. (Bachelor thesis)



Bc. Markéta Bašusová
Synthesis of Deuterated Standards of New Synthetic Drugs. (Bachelor thesis)



Bc. Kateřina Bezděková
Identification of psychoactive substances and their metabolites in wastewater. (Bachelor thesis)



Bc. Tereza Maříková
Development of preparative HPLC enantioseparation methods for cathinones. (Bachelor thesis)



Bc. Magdaléna Vágnerová
Pharmacokinetics study of deschloroketamine by HPLC-MS. (Bachelor thesis)



Bc. Lucie Svobodová
Identification of new psychoactive substances by Raman and infrared spectroscopy. (Bachelor thesis)



Bc. Barbora Mužíková
Identification of new psychoactive substances by NMR. (Bachelor thesis)




 
2017





PharmDr. Petra Mikšátková, Ph.D.

New sources of bioactive polyphenols. (Dissertation)



Ing. Soňa Švejcarová
Determination of impurity profile of methamphetamine synthetized from various available precursors. (Masters thesis)



Bc. Kamila Cahová
Pharmacokinetic study of the synthetic cannabinoid JWH-073 by HPLC-MS. (Bachelor thesis)



Bc. Natalie Kolderová
Chiral separation of synthetic cathinones. (Bachelor thesis)



Bc. Tereza Pánková
Determination of the metabolic profile of deschloroketamine in biological matrix by HPLC-MS. (Bachelor thesis)




 
2016





Ing. Kateřina Bártová
Synthesis of dyes for diamond-based dye-sensitized solar cells. (Masters thesis)



Ing. Pavlína Pamánková
The analysis of phytocannabinoids in cannabis plants by gas chromatography-mass spectrometry. (Masters thesis)



Ing. Barbara Feriančiková
Analysis of psychoactive compound MDPV in biological matrices by liquid chromatography-mass spectrometry. (Masters thesis)



Ing. Michal Holík
Analysis of ketamine and norketamine in biological matrices by liquid chromatography-mass spectrometry. (Masters thesis)



Ing. Aneta Pospíšilová
Polymer conjugates of muscarinic acetylcholine receptor ligands as targeted moieties for oncological diagnostics and therapy. (Masters thesis) Collaboration with Institute of Macromolecular Chemistry, Czech Academy of Sciences



Bc. Pavla Průchová
HPLC-MS quantitative analysis of selected steroidal saponins in commercial food supplements containing Tribulus terrestris. (Bachelor thesis)



Bc. David Mervart
Analysis of psychoactive substances in biological matrix by liquid chromatography coupled with mass spectroscopy. (Bachelor thesis)



Bc. Sabina Kučerová
Qualitative analysis of drug users urine samples by lateral flow immunoassay method. (Bachelor thesis)



Bc. Klára Gotvaldová
Analysis of psychoactive substances in Psilocybe species by LC-MS. (Bachelor thesis)



Bc. Anna Možná
Analysis of synthetic cannabinoids mixtures by capillary electrophoresis. (Bachelor thesis)



Bc. Simona Janičová
Biologically active compounds in psychoactive plant Rhodiola rosea and their detection. (Bachelor thesis)



Bc. Mária Dvořáčková
Biologically active compounds in psychoactive plant Leonotis leonurus and their detection. (Bachelor thesis)



Bc. Nikola Vrzáčková
Biologically active compounds in psychoactive plant Passiflora incarnata and their detection. (Bachelor thesis)



Bc. Nicola Procházková
Biologically active compounds in psychoactive plant Evodia Rutaecarpa and their detection. (Bachelor thesis)



Bc. Zuzana Tučková
Synthesis of novel substituted thiiranes as potential irreversible inhibitors of glutamate carboxypeptidase II. (Bakalářská práce)



Bc. Karolína Zvolská
Synthesis and charakterisation of metabilites of substituted amphetamines. (Bachelor thesis)





 
2015






Ing. Pavel Švec

Synthesis of New Choline Transporter Ligands for Oncological Diagnostics and Therapy. (Masters thesis)
Collaboration with Institute of Macromolecular Chemistry, Czech Academy of Sciences





Ing. Bronislav Jurásek

Synthesis and Characterisation of Methoxetamine Metabolites. (Masters thesis)





Ing. Markéta Marková

Analysis of methoxetamine in biological matrices by liquid chromatography-mass spectrometry. (Masters thesis)





Ing. Michael Valkovič

Stability study of the synthetic cannabinoids. (Masters thesis)





Bc. Šárka Bicanová
Components of immunochemical kits for the detection of synthetic cannabinoids. (Bachelor thesis)





Bc. Soňa Švejcarová

Determination of yield of pseudoephedrine extraction from various medicinal drugs. (Bachelor thesis)






Bc. Ondřej Slavík

Quantitative analysis of neurotransmitter in rat brain microdialysates by LC-MS. (Bachelor thesis)




Bc. Klára Burianová

Analysis of steroids in biological matrix by liquid chromatography coupled with mass spectroscopy. (Bachelor thesis)





Bc. Soňa Šimková

Biologically active compounds in psychoactive plant Hoodia gordonii. (Bachelor thesis)





Bc. Veronika Pivoňková

Biologically active compounds in psychoactive plant Leuzea carthamoides. (Bachelor thesis)





Bc. Jakub Petřík

Biologically active compounds in psychoactive plant Scutellaria lateriflora. (Bachelor thesis)





Bc. Martina Hegrová

Analysis of psychoactive compounds based on synthetic cathinones by capillary electrophoresis. (Bachelor thesis)




 
2014




Ing. Michal Maryška
Components of immunochemical kits for the detection of synthetic tryptamines derivatives. (Masters thesis)





Bc. Kateřina Bártová

Components of immunochemical kits for the detection of synthetic phenylethylamine derivatives. (Bachelor thesis)




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