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[platne_od] => 13.03.2020 21:32:00
[zmeneno_cas] => 13.03.2020 21:32:28.057112
[zmeneno_uzivatel_jmeno] => Michal Maryška
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[paticka_budova_a_popis] => Department of Organic Chemistry and Department of Chemistry of Natural Compounds are located on the 2nd floor
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Forensic laboratory of biologically active substances
Technická 3, 166 28 Prague 6
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Employees |
Students |
Alumni |
Steroids
Instrumental analysis
Immunochemical diagnostics
New psychoactive substances (NPS)
General information
- Categorization and screening of NPS
- Legislative related to NPS
Pharmacology
- Pharmacodynamics
- Pharmacokinetics
Analysis
- Electrophoresis
- Enantioseparation
Synthesis
- Components for immunochemical assays
- Preparation of analytical standards
Forensic and toxicological research
Synthesis of metabolites
Precursors
Drug profiling
Quantitative analysis of illicit substances in real samples
Drug counterfeits
Neurotransmiters
Microdialyzate analysis
Diagnostics and potential new drugs
Novel psychopharmaceuticals
Cannabinoids
Bioactive amines
Inhibitors of tryptophan metabolism
Natural bioactive substances
Active compounds from Cannabis plants
Etnobotanics
"Magic mushrooms" - Psilocybe mushrooms
Psilocybin
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Ing. Radek Jurok, Ph.D.
- Organická chemie A - B110001
- Organická chemie B - B110002
- Laboratoř organické chemie I - B110005
- Laboratoř organické chemie II - B110006
- Laboratoř specializace - syntéza léčiv - M110010
- Laboratorní projekt programu SVL II - M150009
PharmDr. Petra Cihlářová, Ph.D.
- Rostlinné léky a tradiční medicina - N342025
- Moderní separační metody s hmotnostní detekcí/Recent separation methods with mass-spectrometry detection - P342005/AP342005
- Biologicky aktivní přírodní látky/Bioactive Natural Compounds - N342009/S342009/S342009A
Mgr. Edita Kofroňová, Ph.D.
- Izolace a identifikace přírodních látek - N342022
- Optimalizace kapalinové chromatografie - D342002
- Plynová chromatografie a hmotnostní detektor - D342005
Ing. Elena Prokudina, Ph.D.
- Izolace a identifikace přírodních látek - N342022
- Izolace a separace molekul - M342005
- Optimalizace kapalinové chromatografie - D342002
- Plynová chromatografie a hmotnostní detektor - D342005
- Moderní separační metody s hmotnostní detekcí/Recent separation methods with mass-spectrometry detection - P342005/AP342005
- Laboratoř pro střední školy - CZV00012
Ing. Natálie Kolderová
Mgr. Alžběta Nemeškalová
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Journal articles:
|
Dobšíková, K.; Taušová, T.; Fagan, P.; Paškanová, N.; Kuchař, M.; Čejka, J.; Setnička, V. Solid-State Vibrational Circular Dichroism: Methodology and Application for Amphetamine Derivatives. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2024, 305, 123486. |
2023
Journal articles:
2022
Journal articles:
|
Jurásek, B.; Rimpelová, S.; Babor, M.; Čejka, J.; Bartůněk, V.; Kuchař, M. Intriguing Cytotoxicity of the Street Dissociative Anesthetic Methoxphenidine: Unexpected Impurities Spotted. International Journal of Molecular Sciences 2022, 23 (2083), 1–15. |
|
Viktorin, V.; Griškova-Bulanova, I.; Voicikas, A.; Dojčánová, D.; Zach, P.; Bravermanová, A.; Andrashko, V.; Tylš, F.; Korčák, J.; Viktorinová, M.; Koudelka, V.; Hájková, K.; Kuchař, M.; Horáček, J.; Brunovský, M.; Páleníček, T. Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience. Journal of Personalized Medicine 2022, 12 (6). |
|
van Elk, M.; Fejer, G.; Lempe, P.; Prochazckova, L.; Kuchar, M.; Hajkova, K.; Marschall, J. Effects of Psilocybin Microdosing on Awe and Aesthetic Experiences: A Preregistered Field and Lab-Based Study. Psychopharmacology (Berl) 2022, 239 (6), 1705–1720. |
|
Šíma, M.; Bobek, D.; Cihlářová, P.; Ryšánek, P.; Roušarová, J.; Beroušek, J.; Kuchař, M.; Vymazal, T.; Slanař, O. Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin. Pharmaceutics 2022, 14 (8), 1627. |
|
Sanz, C.; Cavanna, F.; Muller, S.; de la Fuente, L.; Zamberlan, F.; Palmucci, M.; Janeckova, L.; Kuchar, M.; Carrillo, F.; García, A. M.; Pallavicini, C.; Tagliazucchi, E. Natural Language Signatures of Psilocybin Microdosing. Psychopharmacology (Berl) 2022, 239 (9), 2841–2852. |
|
Kretschmer, J.; David, T.; Dračínský, M.; Socha, O.; Jirak, D.; Vít, M.; Jurok, R.; Kuchař, M.; Císařová, I.; Polasek, M. Paramagnetic Encoding of Molecules. Nature Communications 2022, 13 (1), 1–12. |
|
Cavanna, F.; Muller, S.; de la Fuente, L. A.; Zamberlan, F.; Palmucci, M.; Janeckova, L.; Kuchar, M.; Pallavicini, C.; Tagliazucchi, E. Microdosing with Psilocybin Mushrooms: A Double-Blind Placebo-Controlled Study. Translation Psychiatry 2022, 12 (1), 1–11. |
|
Brancato, A.; Castelli, V.; Lavanco, G.; D’Amico, C.; Feo, S.; Pizzolanti, G.; Kuchar, M.; Cannizzaro, C. Social Stress under Binge-like Alcohol Withdrawal in Adolescence: Evidence of Cannabidiol Effect on Maladaptive Plasticity in Rats. Psychological Medicine 2022, 1–13. |
|
Bavlovič Piskáčková, H.; Nemeškalová, A.; Kučera, R.; Pedersen-Bjergaard, S.; Najmanová, V.; Štěrbová-Kovaříková, P.; Kuchař, M.; Sýkora, D. Advanced Microextraction Techniques for the Analysis of Amphetamines in Human Breast Milk and Their Comparison with Conventional Methods. Journal of Pharmaceutical and Biomedical Analysis 2022, 210 (114549). |
2021
Journal articles:
|
Kosović, E.; Sýkora, D.; Kuchař, M. Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution. Pharmaceutics 2021, 13 (3). https://doi.org/10.3390/pharmaceutics13030412. |
|
Šuláková, A.; Nykodemová, J.; Palivec, P.; Jurok, R.; Rimpelová, S.; Leonhardt, T.; Šíchová, K.; Páleníček, T.; Kuchař, M. 25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. Elegans—Structure Determination and Synthesis of the Most Abundant Metabolites. Metabolites 2021, 11 (4). https://doi.org/10.3390/metabo11040212 |
|
Šuláková, A.; Nykodemová, J.; Palivec, P.; Jurok, R.; Rimpelová, S.; Leonhardt, T.; Šíchová, K.; Páleníček, T.; Kuchař, M. 25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. Elegans—Structure Determination and Synthesis of the Most Abundant Metabolites. Metabolites 2021, 11 (4). https://doi.org/10.3390/metabo11040212 |
|
Fagan, P.; Spálovská, D.; Jurok, R.; Kuchař, M.; Schrenková, V.; Setnička, V. Structural Analysis of MDMA in Solution by Methods of Chiroptical Spectroscopy Supported by DFT Calculations. Vib. Spectrosc. 2021, 114 (103255). https://doi.org/10.1016/j.vibspec.2021.103255 |
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Šíma, M.; Michaličková, D.; Ryšánek, P.; Cihlářová, P.; Kuchař, M.; Lžičařová, D.; Beroušek, J.; Hartinger, J. M.; Vymazal, T.; Slanař, O. No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses. Pharmaceutics 2021, 13 (8). https://doi.org/10.3390/pharmaceutics13081156 |
|
Fagan, P.; Spálovská, D.; Kuchař, M.; Černohorský, T.; Komorousová, L.; Kocourková, L.; Setnička, V. Ecstasy Tablets: Rapid Identification and Determination of Enantiomeric Excess of MDMA. Forensic Chem. 2021, 26 (100381). https://doi.org/10.1016/j.forc.2021.100381 |
|
Spálovská, D.; Pekárek, T.; Kuchař, M.; Setnička, V. Comparison of Genuine, Generic and Counterfeit Cialis Tablets Using Vibrational Spectroscopy and Statistical Methods. J. Pharm. Biomed. Anal. 2021, 206. https://doi.org/10.1016/j.jpba.2021.114383 |
|
Spálovská, D.; Paškan, M.; Jurásek, B.; Kuchař, M.; Kohout, M.; Setnička, V. Structural Spectroscopic Study of Enantiomerically Pure Synthetic Cathinones and Their Major Metabolites. New J. Chem. 2021, 45 (2), 850–860. https://doi.org/10.1039/d0nj05065b |
|
Di Bartolomeo, M.; Stark, T.; Maurel, O. M.; Iannotti, F. A.; Kuchar, M.; Ruda-Kucerova, J.; Piscitelli, F.; Laudani, S.; Pekarik, V.; Salomone, S.; Arosio, B.; Mechoulam, R.; Maccarrone, M.; Drago, F.; Wotjak, C. T.; Di Marzo, V.; Vismara, M.; Dell’Osso, B.; D’Addario, C.; Micale, V. Crosstalk between the Transcriptional Regulation of Dopamine D2 and Cannabinoid CB1 Receptors in Schizophrenia: Analyses in Patients and in Perinatal Δ9-Tetrahydrocannabinol-Exposed Rats. Pharmacol. Res. 2021, 164 (July 2020), 105357. https://doi.org/10.1016/j.phrs.2020.105357 |
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Shishkanova, T. V.; Štěpánková, N.; Tlustý, M.; Tobrman, T.; Jurásek, B.; Kuchař, M.; Trchová, M.; Fitl, P.; Vrňata, M. Electrochemically Oxidized 15-Crown-5 Substituted Thiophene and Host-Guest Interaction with New Psychoactive Substances. Electrochim. Acta 2021, 373 (137862). https://doi.org/10.1016/j.electacta.2021.137862 |
|
Charalambous, C.; Havlickova, T.; Lapka, M.; Puskina, N.; Šlamberová, R.; Kuchar, M.; Sustkova-Fiserova, M. Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. Int. J. Mol. Sci. 2021, 22 (5), 1–22. https://doi.org/10.3390/ijms22052397 |
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Belhacova, L.; Bibova, H.; Marikova, T.; Kuchar, M.; Zouzelka, R.; Rathousky, J. Removal of Ampicillin by Heterogeneous Photocatalysis: Combined Experimental and DFT Study. Nanomaterials 2021, 11 (8), 1992. https://doi.org/10.3390/nano11081992 |
2020
Journal articles:
|
Madsen, M. K.; MacDonald Fisher, P.; Stenbæk, D. S.; Kristiansen, S.; Burmester, D.; Lehel, S.; Páleníček, T.; Kuchař, M.; Svarer, C.; Ozenne, B.; Knudsen, G. M. A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Europian Neuropsychopharmacology 2020, in press (available online). |
|
Králík, F.; Fagan, P.; Kuchař, M.; Setnička, V. Structure of heroin in a solution revealed by chiroptical spectroscopy. Chirality 2020, in press (available online). |
|
Huml, L.; Havlová, D.; Longin, O.; Staňková, E.; Holubová, B.; Kuchař, M.; Prokudina, E.; Rottnerová, Z.; Zimmermann, T.; Drašar, P.; Lapčík, O.; Jurášek, M. Stanazolol derived ELISA as a sensitive forensic tool for the detection of multiple 17α-methylated anabolics. Steroids 2020, 155, in press (available online). |
|
Hájková, K.; Jurásek, B.; Čejka, J.; Štefková, K.; Páleníček, T.; Sýkora, D.; Kuchař, M. Synthesis and identification of deschloroketamine metabolites in rats' urine and a quantification method for deschloroketamine and metabolites in rats' serum and brain tissue using liquid chromatography tandem mass spectrometry. Drug Testing and Analysis 2020, 12 (3), 343–360. |
|
Shishkanova, T. V.; Vatrsková, L; Spálovská, D.; Králík, F.; Cuřínová, P.; Winkler, M.; Budka, J.; Jurásek, B.; Kuchař, M.; Setnička, V. Complexation of cathinones by 4-tert-butylcalix[4]arene tetra-acetate as a possible technique for forensic analysis. Forensic Toxicology 2020, 38, 70–78. |
2019
Journal articles:
|
Knytl, P.;Voráčková, V.; Dorazilová, A.; Rodriguez, M.; Cvrčková, A.; Kofroňová, E.; Kuchař, M.; Kratochvílová, Z.; Šustová, P.; Čerešňáková, S.; Mohr, P. Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings. Frontiers in Psychiatry 2019, 10, article 390. |
|
Guricova, M.; Pinc, J.; Malinčík, J.; Rak, J.; Kuchař, M.; Bartůněk, V. Rare earth nanofluorides: synthesis using ionic liquids. Reviews in Inorganic Chemistry 2019, 39 (2), 77–90. |
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Uthaug, M. V.; Lancelotta, R.; van Oorsouw, K.; Kuypers, K. P. C.; Mason, N.; Rak, J.; Šuláková, A.; Jurok, R.; Maryška, M.; Kuchař, M.; Páleníček, T.; Riba, J.; Ramaekers, J. G. A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology 2019, 236 (9), 2653–2666. |
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Nemeškalová, A.; Bursová, M.; Sýkora, D.; Kuchař, M.; Čabala, R.; Hložek, T. Salting out assisted liquid-liquid extraction for liquid chromatography tandem-mass spectrometry determination of amphetamine-like stimulants in meconium. Journal of Pharmaceutical and Biomedical Analysis 2019, 172, 42–49. |
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Drazanova, E.; Ruda-Kucerova, J.; Kratka, L.; Stark, T.; Kuchar, M.; Maryska, M.; Drago, F.; Starcuk Jr., Z.; Micale, V. Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats. Scientific Reports 2019, 9, article 6062. |
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Spálovská, D.; Maříková, T.; Kohout, M.; Králík, F.; Kuchař, M.; Setnička, V. Methylone and pentylone: structural analysis of new psychoactive substances. Forensic Toxicology 2019, 37, 366–377. |
|
Stark, T.; Giurdanella, G.; Pekarik, V.; Kuchar, M.; Babinska, Z.; Ruda-Kucerova, J.; Salomone, S.; Mechoulam, R.; Drago, F.; Sulcova, A.; Micale, V. Peripubertal treatment with cannabidiol reverses behavioral alterations in ∆9-THC animal model of schizophrenia. European Neuropsychopharmacology 2019, 29 (S1), S257–S258. |
|
Di Bartolomeo, M.; Stark, T.; Pucci, M; Drago, F.; Kuchař, M.; Mauro, M.; Vincenzo, M; Claudio, D. Effects of perinatal cannabis exposure on transcriptional regulation of dopamine receptor d2 and cannabinoid receptor 1 in rats at adulthood. European Neuropsychopharmacology 2019, 29 (S1), S109–S110. |
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Holubová, B.; Mikšátková, P.; Kuchař, M.; Karamonová, L; Lapčík, O.; Fukal, L. Immunochemical techniques for anabolic androgenic steroid: matrix effects study for food supplements. European Food Research and Technology 2019, 245, 1011–1019. |
|
Šuláková, A.; Fojtíková, L.; Holubová, B.; Bártová, K.; Lapčík, O.; Kuchař, M. Two immunoassays for the detection of 2C-B and related hallucinogenic phenethylamines. Journal of Pharmacological and Toxicological Methods 2019, 95, 36–46. |
|
Jurásek, B.; Bartůněk, V.; Huber, Š.; Kuchař, M. X-Ray powder diffraction – A non-destructive and versatile approach for the identification of new psychoactive substances. Talanta 2019, 195, 414–418. |
Patents:
|
Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M.; Holubová, B. Použití derivátu tryptaminu. CZ Patentový spis 307719, Feb 06, 2019. |
2018
Journal articles:
|
Jurásek, B.; Králík, F.; Rimpelová, S.; Čejka, J.; Setnička, V.; Ruml, T.; Kuchař, M.; Kohout, M. Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic. New Journal of Chemistry 2018, 42 (24), 19309–20250. |
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Prochazkova, L.; Lippelt, D.P.; Colzato, L.S.; Kuchar, M.; Sjoerds, Z.; Hommel, B. Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting. Psychopharmacology 2018, 235, 3401–3413. |
|
Uttl, L.; Szczurowska, E.; Hájková, K.; Horsley, R.R.; Štefková, K.; Hložek, T.; Šichová, K.; Balíková, M.; Kuchař, M.; Micale, V.; Páleníček, T. Behavioral and pharmacokinetic profile of indole-derived synthetic cannabinoids JWH-073 and JWH-210 as compared to the phytocannabinoid ∆9-THC in rats. Frontiers in Neuroscience 2018, 12, article 703. |
|
Jurásek, B.; Babor, M.; Huber, Š.; Kuchař, M. X-ray powder diffraction data for methoxmetamine hydrochloride, C14H20ClNO2. Powder Diffraction 2018, 33 (3), 242–245. |
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Řezanková, K.; Kohoutová, R.; Kuchař, M.; Král, V.; Řezanka, P. Enantioseparation of Novel Psychoactive Chiral Amines and Their Mixture by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors. Chem. Pap. 2018, 72, 2737–2743. |
|
Křížek, T.; Bursová, M.; Horsley, R.; Kuchař, M.; Tůma, P.; Čabala, R.; Hložek, T. Menthol-Based Hydrophobic Deep Eutectic Solvents: Towards Greener and Efficient Extraction of Phytocannabinoids. J. Clean. Prod. 2018, 193, 391–396. |
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Horsley, R. R.; Lhotkova, E.; Hajkova, K.; Feriancikova, B.; Himl, M.; Kuchar, M.; Páleníček, T. Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat. Front. Psychiatry 2018, 9, article 144. |
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Maryška, M.; Fojtíková, L.; Jurok, R.; Holubová, B.; Lapčík, O.; Kuchař, M.; Use of novel haptens in the production of antibodies for the detection of tryptamines. RSC Adv. 2018, 8 (29), 16243–16250. |
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Sýkorová, S.; Fojtíková, L.; Kuchař, M.; Mikšátková, P.; Karamonová, L.; Fukal, L.; Lapčík, O.; Holubová, B. Sensitive Enzyme Immunoassay for Screening Methandienone in Dietary Supplements. Food Addit. Contam. Part A 2018, 35 (9), 1653–1661. |
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Králík, F.; Jirmásek, P.; Kuchař, M.; Setnička, V. Chiroptical and Vibrational Spectroscopic Study of Genuine and Counterfeit Medicines Containing Tadalafil. Chirality 2018, 30 (5), 560–567. |
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Spálovská, D.; Králík, F.; Kohout, M.; Jurásek, B.; Habartová, L.; Kuchař, M.; Setnička, V. Structure Determination of Butylone as a New Psychoactive Substance Using Chiroptical and Vibrational Spectroscopies. Chirality 2018, 30 (5), 548–559. |
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Šíchová, K.; Pinterová, N.; Židková, M.; Horsley, R. R.; Lhotková, E.; Štefková, K.; Vejmola, Č.; Uttl, L.; Balíková, M.; Kuchař, M.; Páleníček, T. Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats. Front. Psychiatry 2018, 8, article 306. |
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Jirouskova, M.; Nepomucka, K.; Oyman-Eyrilmez, G.; Kalendova, A.; Havelkova, H.; Sarnova, L.; Chalupsky, K.; Schuster, B.; Benada, O.; Miksatkova, P.; Kuchar, M.; Fabian, O.; Sedlacek, R.; Wiche, G.; Gregor, M. Plectin Controls Biliary Tree Architecture and Stability in Cholestasis. J. Hepatol. 2018, 68 (5), 1006–1017. |
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Fojtíková, L.; Šuláková, A.; Blažková, M.; Holubová, B.; Kuchař, M.; Mikšátková, P.; Lapčík, O.; Fukal, L. Lateral Flow Immunoassay and Enzyme Linked Immunosorbent Assay as Effective Immunomethods for the Detection of Synthetic Cannabinoid JWH-200 Based on the Newly Synthesized Hapten. Toxicol. Reports 2018, 5, 65–75. |
2017
Journal articles:
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Jurasek, B.; Himl, M.; Jurok, R.; Hajkova, K.; Vobinuskova, A.; Rezanka, P.; Kuchar, M. Synthesis of Methoxetamine, Its Metabolites and Deuterium Labelled Analog as Analytical Standards and Their HPLC and Chiral Capillary Electrophoresis Separation. RSC Adv. 2017, 7 (89), 56691–56696. |
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Štefková, K.; Židková, M.; Horsley, R. R.; Pinterová, N.; Šíchová, K.; Uttl, L.; Balíková, M.; Danda, H.; Kuchař, M.; Páleníček, T. Pharmacokinetic, Ambulatory, and Hyperthermic Effects of 3,4-Methylenedioxy-N-Methylcathinone (Methylone) in Rats. Frontiers in Psychiatry 2017, 8, article 232. |
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Hložek, T.; Uttl, L.; Kadeřábek, L.; Balíková, M.; Lhotková, E.; Horsley, R. R.; Nováková, P.; Šíchová, K.; Štefková, K.; Tylš, F.; Kuchař, M.; Páleníček, T. Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC. European Neuropsychopharmacology 2017, 27 (12), 1223–1237. |
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Maixner, J.; Jurásek, B.; Himl, M.; Kuchař, M.; Babor, M. X-Ray Powder Diffraction Data for Methoxetamine Hydrochloride, C15H22ClNO2. Powder Diffraction 2017, 32 (4), 265–267. |
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Maixner, J.; Jurásek, B.; Kohout, M.; Kuchař, M.; Kačer, P. X-ray powder diffraction data for (S)-Deschloroketamine hydrochloride, C13H18ClNO. Powder Diffraction 2017, 32 (3), 193–195. |
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Fagan, P.; Kocourková, L.; Tatarkovic, M.; Králík, F.; Kuchař, M.; Setnička, V.; Bouř, P. Cocaine Hydrochloride Structure in Solution Revealed by Three Chiroptical Methods. ChemPhysChem 2017, 18 (16), 2258–2265. |
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Fojtíková, L.; Holubová, B.; Kuchař, M. New psychoactive substances. Chemické listy 2017, 111 (4), 234–238. |
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Androvicová, R.; Horáček, J.; Tintěra, J.; Rýdlo, J.; Jezová, D.; Balíková, M.; Hložek, T.; Mikšátková, P.; Kuchař, M.; Hlinka, J.; Roman, M. Acute Cannabis Intoxication and the Brain's Response to Visual Erotica: An Fmri Study. The Journal of Sexual Medicine 2017, 14 (5), e253. DOI: 10.1016/j.jsxm.2017.04.250. |
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Androvicova, R.; Horáček, J.; Tintěra, J.; Hlinka, J.; Rydlo, J. Ježová, D.; Balíková, M.; Hložek, T.; Mikšátková, P.; Kuchař, M.; Roman, M.; Tomíček, P.; Tylš, F.; Viktorinová, M.; Páleníček, T. Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study. Psychopharmacology 2017, 243 (13), 1933. |
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Kolderová, N.; Neveselý, T.; Šturala, J.; Kuchař, M.; Holakovský, R.; Kohout, M. Enantioseparation of Chiral Sulfoxides on Amylose-Based Columns: Comparison of Normal Phase Liquid Chromatography and Supercritical Fluid Chromatography. Chromatographia 2017, 80 (4), 547–557. |
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Kučerová, S.; Kuchař, M. Průzkum zneužívání omamných a psychotropních látek u klientů centra substituční léčby. Drugs and Forensics Bulletin 2017, 1, 16–25. |
Patents:
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Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Holubová, B. Derivát syntetického kanabinoidu, způsob přípravy a použití. CZ Patentový spis 306547, 2017. |
2016
Journal articles:
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Bartůněk, V.; Huber, Š.; Luxa, J.; Sofer, Z.; Kuchař, M.; Dobrovolný, K. Facile Synthesis of Magnetic Cobalt Nano-foam by Low-temperature Thermal Decomposition of Cobalt Glycerolate. Micro & Nano Letters 2017, 12 (5), 278–280. |
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Nemeškalová, A.; Kuchař, M. Přírodní a syntetické opiáty. Drugs and Forensics Bulletin 2016, 4, 11–17. |
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Bartůněk, V.; Rak, J.; Pelánková, B.; Junková, J.; Mezlíková, M.; Král, V.; Kuchař, M.; Engstová, H.; Ježek, P.; Šmucler, R. Large scale preparation of up- converting YF3: YbEr nanocrystals with various sizes by solvothermal syntheses using ionic liquid bmimCl. Journal of fluorine chemistry 2016, 188, 14–17. |
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Gotvaldová, K.; Kuchař, M. Lysohlávky - Halucinogenní houby z rodu Psilocybe. Drugs and Forensics Bulletin 2016, 3, 8–14. |
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Lehmert, K.; Šťastná, P.; Kuchař, M.; Hájková, K. Dopady nelegální varny metamfetaminu na lidské zdraví a životní prostředí. Drugs and Forensics Bulletin 2016, 3, 15–21. |
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Bartůněk, V.; Dobrovolný, K.; Švecová, M.; Matějka, P.; Šída, P.; Pokorný, P.; Kuchař, M.; Černá, E. Obtaining Black Carbon—A Simple Method for the Safe Removal of Mineral Components from Soils and Archaeological Layers. Archaeometry, 2017, 59 (2), 346–355. |
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Krysova, H.; Bartoň, J.; Petrák, V.; Jurok, R.; Kuchař, M.; Cígler, P.; Kavan, L. Efficiency and Stability of Spectral Sensitization of Boron-Doped-Diamond Electrode through Covalent Anchoring of a Donor-Acceptor Organic Chromophore (P1). Phys Chem Chem Phys 2016, 18, 16444–16450. |
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Jurášek, M.; Göselová, S.; Mikšátková, P.; Holubová, B.; Vyšatová, E.; Kuchař, M.; Fukal, L.; Lapčík, O.; Drašar, P. Highly sensitive avidin-biotin ELISA for detection of nandrolone and testosterone in dietary supplements. Drug Test Anal, 2017, 9 (4), 553–560. |
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Hegrová, M.; Řezanková, K.; Kuchař, M.; Řezanka, P. Separace enantiomerů kathinonů kapilární elektroforézou s využitím cyklodextrinů jako chirálních selektorů. Chemické listy 2016, 110, 200–203. |
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Pamánková, P.; Kuchař, M. Analýza a využití konopí v medicíně. Drugs and Forensics Bulletin 2016, 2, 29–39. |
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Horsley, R. R.; Lhotkova, E.; Hajkova, K.; Jurasek, B.; Kuchar, M.; Palenicek, T. Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue—Behavioural, pharmacokinetic and metabolic studies in the Wistar rat. Brain Res Bull 2016, 126 Part 1, 102–110. |
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Fojtíková, L.; Fukal, L.; Blažková, M.; Sýkorová, S.; Kuchař, M.; Mikšátková, P.; Lapčík, O.; Holubová, B. Development of enzyme-linked immunosorbent assay for determination of boldenone in dietary supplements. Food Anal Method 2016, 9 (11), 3179–3186. |
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Páleníček, T.; Lhotková, E.; Žídková, M.; Balíková, M.; Kuchař, M.; Himl, M.; Mikšátková, P.; Čegan, M.; Valeš, K.; Tylš, F.; Horsley, R. R. Emerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and LD50 in rats. Prog Neuropsychopharmacol Biol Psychiatry 2016, 69 (1), 49–59. |
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Jurásek, B.; Kuchař, M. Methoxetamine. Drugs and Forensics Bulletin 2016, 1, 27–31. |
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Bartůněk, V.; Junková, J.; Babuněk, M.; Ulbrich, P.; Kuchař, M.; Sofer, Z. Synthesis of spherical amorphous selenium nano and microparticles with tunable sizes. Micro Nano Lett 2016, 11 (2), 91–93. |
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Wolrab, D.; Frühauf, P.; Moulisová, A.; Kuchař, M.; Gerner, C.; Lindner, W.; Kohout, M.; Chiral separation of new designer drugs (Cathinones) on chiral ion-exchange type stationary phases. J Pharm Biomed Anal 2016, 120, 306–315. |
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Hájková, K.; Jurásek, B.; Sýkora, D.; Páleníček, T.; Mikšátková, P.; Kuchař, M. Salting-out assisted liquid-liquid extraction as a suitable approach for determination of methoxetamin in large sets of tissue samples. Anal Bioanal Chem 2016, 408 (4), 1171–1181. |
Patents:
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Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O. Derivát syntetického kanabinoidu, způsob jeho přípravy a využití. CZ Patentový spis 305780, 2016. |
Function samples:
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči- dimethyltryptamin (DMT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - dimethyltryptamin (DMT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči - 5-methoxy-N,N-dimethyltryptamin (5-MeO-DMT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 5-methoxy-N,N-dimethyltryptamin (5-MeO-DMT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - JWH-200 (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - diisopropyltryptamin (DiPT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči- diisopropyltryptamin (DiPT) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 4-brom-2,5-dimethoxyfenylethylamin (2-CB) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog z moči - 4-brom-2,5-dimethoxyfenylethylamin (2-CB) (příbalový leták) |
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Kuchař, M.; Pravečková, M.; Fojtíková, L.; Šuláková, A.; Maryška, M.; Lapčík, O. Rychlý imunochemický test k detekci nových syntetických drog ze slin - 5-jod-2-aminoindan (5-IAI) (příbalový leták) |
Conference proceedings:
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Kuchař, M. Nové syntetické drogy a jejich možná rizika. Snižování škod a drogy, Snižování škod a drogy; Hanková, O., Ed.; 2016; pp 83–88. |
2015
Journal articles:
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Bartůněk, V.; Pinca, J.; Ulbrich, P.; Rak, J.; Pelánková, B.; Král, V.; Kuchař, M.; Ježek, P.; Engstová, H.; Smolková, K. Tunable rapid microwave synthesis of up-converting hexagonal NaYxGdyYbzEr(1−x−y−z)F4 nanocrystals in large quantity. J. Fluorine Chem. 2015, 178, 56–60. |
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Prokudina, E. A.; Prchalová, J.; Vyšatová, E.; Kuchař, M.; Rajchl, A.; Lapčík, O. Analysis of anabolic androgenic steroids by direct analysis in real time ionization with time-of-flight mass spectrometry. International Journal of Mass Spectrometry 2015, 392, 28–33. |
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Hrachovec, M.; Franěk, L.; Kuchař, M. Nelegální výroba heroinu z přípravku Vendal retard. Bulletin Národní protidrogová centrála 2015, 3, 3-6. |
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Hrachovec, M.; Kuchař, M. Červený fosfor – klíčová substance při výrobě metamfetaminu. Bulletin Národní protidrogová centrála 2015, 3, 16-20. |
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Mikšátková, P.; Kuchař, M. Zdravotní rizika užívání anabolických steroidů. Bulletin Národní protidrogová centrála 2015, 3, 21-26. |
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Kuchař, M. Aktuální případy intoxikací v Polsku po užití NPS. Bulletin Národní protidrogová centrála 2015, 3, 38-39. |
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Švejcarová, S.; Sýkora, D.; Kuchař, M. Stanovení extrakčního výtěžku pseudoefedrinu z léčivých přípravků. Bulletin Národní protidrogová centrála 2015, 4, v tisku |
Patents:
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Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M. Imunochromatografický test dimethyltryptaminových drog. Užitný vzor CZ 28938 U1, Dec 07, 2015. |
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Kuchař, M.; Šuláková, A.; Fojtíková, L.; Lapčík, O.; Maryška, M. Imunochromatografický test syntetických kanabinoidů. Užitný vzor CZ 28908 U1, Nov 30, 2015. |
Conference proceedings:
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Šuláková A., Fojtíková L., Kuchař M., Lapčík O.: Development of User Friendly Test for Synthetic Cannabinoid JWH200. The 13-th International Kyoto Conference on New Aspects of Organic Chemistry.Pragram and Abstracts II. Poster PC(D)29, p. 189. Kyoto, November 9-13, 2015. |
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Kuchař M., Roman M.: Analýza psychoaktivních látek ve vlasech, konference Trestně právní a kriminalistické aspekty dokazování, str. 98-109, Praha 13.3.2015, ISBN 978-80-7408-112-5 |
Book chapters and software:
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Kuchař, M. Nové psychoaktivní látky. In Klinická adiktologie, 1st ed.; Kalina, K.; et al. Grada Publishing, a.s: Příbram, 2015; pp 84–95. |
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Kuchař, M.; Hořínek, J.; Svozil, D.; Čermák, J. Database of new synthetic drugs. (RIV/60461373:22310/13:43896676) |
Legislation:
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Kuchař, M.; Novák, P.; Polansky, P.; Rinke, J.; Hrachovec, M. Nařízení vlády č. 243/2015 o seznamech návykových látek. |
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Kuchař, M.; Novák, P.; Polansky, P.; Rinke, J.; Hrachovec, M. Nařízení vlády č. 242/2015 o seznamu výchozích a pomocných látek a jejich ročních množstevních limitech návykových látek. |
by 2015
Journal articles:
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Kuchař, M.; Kitzlerova, A. Nové zneužívané látky v Evropě/ New misused substances in Europe. Bulletin National Drug Headquartes 2014, 4, 3-9. |
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Lehmert, K.; Kuchař, M. CBRNe: Bilý prášek – droga, jed nebo cukr?/ CBRNe: White powder – drugs, poison or sugar?. Bulletin National Drug Headquartes 2014, 3, 23-28. |
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Kuchař, M.; Teplárek, P. Likvidace ilegálních laboratoří sloužících k výrobě metamfetaminu/ Dismatling of clandestine methamphetamine laboratory. Bulletin National Drug Headquartes 2014, 1, 9-13. |
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Bartůněk, V.; Rak, J.; Pelánková, B.; Sofer, Z.; Ulbrich, P.; Kuchař, M.; Král, V. Preparation and luminescent properties of cubic potassium-erbium fluoride nanoparticles. J Fluorine Chem 2013, 156, 363–366. |
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Kuchař, M.; Teplárek, P. EU – China Trade Project. Bulletin National Drug Headquartes 2013, 1, 20-21. |
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Kuchař, M. Nové syntetické drogy – review/New synthetic drugs – review. Bulletin National Drug Headquartes 2012, 4, 25-28. |
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Kuchař, M. Pré-prekursory drog – nové trendy v Evropské Unii/Pré-precursors – new trends in European Union. Bulletin National Drug Headquartes 2012, 4, 3-5. |
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Páleníček, T.; Kuchař, M. Je možná identifikace nových syntetických drog (NSD) pomocí orientačních testů?/Can Rapid Tests Be Used to Detect and Identify New Synthetic Drugs (NSDs)? Addictology 2011, 11(4), 208-214. |
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Vaněček, M.; Kuchař, M. Fentanyl/Fentanyl. Bulletin National Drug Headquartes 2011, 4, 3-4. |
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Hrachovec, M.; Kuchař, M. Nebezpečné chemikálie a Pyromeeting 2011/Dangerous Chemicals and Pyromeeting 2011. Bulletin National Drug Headquartes 2011, 3, 18-21. |
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Tomíček, P.; Kuchař, M. Cvičení Peaceful-Dragon/Training Peaceful Dragon. Bulletin National Drug Headquartes 2011, 3, 14-17. |
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Kuchař, M. „Mephedron, droga roku 2010/Mephedrone, drugs of the year 2010“. Bulletin National Drug Headquartes 2010, 3, 36-37. |
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Kuchař, M. Příměsi v nelegálních drogách – identifikace a jejich profil/Cutting agents in illicit drugs. Bulletin National Drug Headquartes 2010, 2, 43-44. |
Conference proceedings:
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Goselova, S.; Holubova, M.; Blazkova, M.; Jurok, R.; Huml, L.; Kuchar, M.; Lapcik, O.; Fukal, L. The development of a sensitive immunoassay for the detection of new synthetic drugs, SW05.S23–18 The FEBS Journal 2013, 280 (2). |
Legislation:
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Kuchař, M.; Ondroušková, A.; Novák, P.; Polansky, P.; Roman, M. Nařízení vlády č. 463/2013 o seznamech návykových látek. |
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Kuchař, M.; Ondroušková, A.; Novák, P.; Hrachovec, M. Nařízení vlády č. 458/2013 o seznamu výchozích a pomocných látek a jejich ročních množstevních limitech. |
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Kuchař, M.; Ondroušková, A.; Hlásenský, I.; Novák, P.; Polansky, P.; Hrachovec, M. Zákon č. 272/2013 Sb. o prekurzorech drog. |
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Kuchař, M.; Ondroušková, A.; Novák, P.; Roman, M. Zákon č. 106/2011 Sb., kterým se mění zákon č. 167/1998 Sb., o návykových látkách a o změně některých dalších zákonů, ve znění pozdějších předpisů. |
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Ongoing projects:
Development of a receptor biochip for the control and regulation of steroid hormones (FW06010206)
- Years: 2023 – 2026
- Principal investigator: ESSENCE LINE, s.r.o.
- Co-investigators: UCT Prague, NIMH Klecany
New psychoactive substances: forensic-toxicology research center (VK01010212)
- Years: 2023 – 2026
- Principal investigator: UCT Prague
- Co-investigator: NIMH Klecany, Police Academy of the Czech Republic
Field quantification of narcotic and psychotropic substances using NIR spectrometry (VK01010137)
- Years: 2023 – 2026
- Principal investigator: UCT Prague
Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression (NU21-04-00307)
- Years: 2021 – 2024
- Principal investigator: NIMH Klecany
- Co-investigators: UCT Prague
Express and portative detection of prohibited substances using innovative techniques: flexible and chiral SERS, selective surface extraction, artificial neural networks. (VJ01010065)
- Years: 2021 – 2025
- Principal investigator: UCT Prague
Pharmacrime – forensic identification of prohormones and counterfeid medicine (VJ01010043)
- Years: 2021 – 2025
- Principal investigator: UCT Prague
- Co-investigators: Ministry of Interior of the Czech Republic
Minimalizace vlivu residuální kontaminace po nelegální výrobě narkotik na zdraví člověka (MPO/FV30483)
- Doba řešení: 2018 – 2021
- Spoluřešitel: Ing. Martin Kuchař, Ph.D.
New synthetic drugs- complex interdisciplinar research center (MV0/VI20172020056)
- Years: 2017 – 2020
- Principal investigator: doc. Ing. Martin Kuchař, Ph.D.
Development of new methods and tools for the detection and investigation of cases of drug counterfeits for better protection of society (MV0/VI20152020048)
- Years: 2015 – 2020
- Principal investigator: doc. Ing. Martin Kuchař, Ph.D.
Minimizing the impact of residual contamination after illicit narcotics production on human health (MPO/FV30483)
- Years: 2018 – 2021
- Co-investigator: doc. Ing. Martin Kuchař, Ph.D.
Ongoing student IGA grants (University research grants):
2023
Study of degradation of endocrine disruptors in aqueous environment using photocatalysts immobilized by the airbrush method (A2_FPBT_2023_031)
- Hlavní řešitel: Ing. Barbora Walderová (Mužíková)
Finished grants I
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AbSciex 6500+ QTRAP + 2D UHPLC
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AbSciex 6500+ QTRAP + 2D UHPLC was funded from research grant MV0/VI20152020048 (2015 - 2020, principal investigator: Ing. Martin Kuchař, Ph.D.) Contact: Ing. Kateřina Hájková |
Preparative LC Waters AutoPurificationTM, Acquity UtraPerformance Convergence Chromatography (UPC2)
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Preparative LC Waters AutoPurificationTM, Acquity UtraPerformance Convergence Chromatography (UPC2) was funded from research grant OP VaVpI 1.05/4.1.00/16.0349 Contact: Ing. Michal Kohout, Ph.D. |
UHPLC/MS system Agilent, 6460 triple quadrupole and 1290 Infinity LC |
UHPLC/MS system Agilent, 6460 triple quadrupole and 1290 Infinity LC, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant CRP C26 (principal investigator: prof. Ing. Zdeněk Wimmer, DrSc.) and co-funded from funds of the Department of Chemistry of Natural Compounds. Contact: Ing. Elena Prokudina, Ph.D.; Prof. Dr. RNDr. Oldřich Lapčík. |
CombiFlash® Rf 200
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Automatic flash chromatography system CombiFlash Rf-200, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant MV0/VG20122015075 (2012 - 2015, principal investigator: prof. Dr. RNDr. Oldřich Lapčík) Contact: Prof. Dr. RNDr. Oldřich Lapčík. |
UHPLC/MS system Agilent, 6550 iFunnel Q-TOF and Infinity 1290 LC |
UHPLC/MS system Agilent, 6550 iFunnel Q-TOF and Infinity 1290 LC, investment of the Department of Chemistry of Natural Compounds. The instrument was funded from research grant OP VaVpI 1.05/4.1.00/16.0349 with financial support from funds of the Department of Chemistry of Natural Compounds. Contact: Ing. Elena Prokudina, Ph.D.; Prof. Dr. RNDr. Oldřich Lapčík. |
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Internal collaborations at UCT Prague
Department od analytical chemistry
- Chiroptical methods group, Vibrational spectroskopy group - prof. Ing. Vladimír Setnička, Ph.D.
- Separation methods group - doc. Dr. RNDr. David Sýkora
Department of informatics and chemistry
- Chemoinformatics group - doc. Mgr. Daniel Svozil, Ph.D.
Department of chemistry of natural compounds
- Analytical and bioanalytical methods group - prof. Dr. RNDr. Oldřich Lapčík
Department of biochemistry and microbiology
- Laboratory of bioaffinity techniques - prof. Ing. Ladislav Fukal, CSc.
- Laboratory of metalomics a bioremediation of heavy metals - doc. Ing. Pavel Kotrba, Ph.D.
- Laboratory of molecular biology a virology - prof. Ing. Tomáš Ruml, CSc.
External collaborations
National institute of mental health - NIMH
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Institute of Macromolecular Chemistry, Czech Academy of Sciences
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Centre of the Region Haná for Biotechnological and Agricultural Research - Palacký University
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Institute of Chemical Process Fundamentals, Czech Academy of Sciences
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University of Amsterdam
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Copenhagen university hospital |
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University of Catania
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National Monitoring Centre for Drugs and Addiction, Office of the Government of the Czech Republic
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Institute of Forensic Medicine and Toxicology, 1st Faculty of Medicine, Charles University
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Department of Pharmacology, 3rd Faculty of Medicine, Charles University
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Police of the Czech Republic – Forensic Institute Prague |
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Czech agriculture and food inspection authority |
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European Monitoring Centre for Drugs and Drug Addiction – EMCDDA |
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Czech olympic committee |
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The laboratory is located on the first floor of building B.
Map - work place of the laboratory
DATA
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[seo_title] => Research grants
[seo_desc] =>
[autor] =>
[autor_email] =>
[obsah] => Ongoing projects:
Development of a receptor biochip for the control and regulation of steroid hormones (FW06010206)
- Years: 2023 – 2026
- Principal investigator: ESSENCE LINE, s.r.o.
- Co-investigators: UCT Prague, NIMH Klecany
New psychoactive substances: forensic-toxicology research center (VK01010212)
- Years: 2023 – 2026
- Principal investigator: UCT Prague
- Co-investigator: NIMH Klecany, Police Academy of the Czech Republic
Field quantification of narcotic and psychotropic substances using NIR spectrometry (VK01010137)
- Years: 2023 – 2026
- Principal investigator: UCT Prague
Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression (NU21-04-00307)
- Years: 2021 – 2024
- Principal investigator: NIMH Klecany
- Co-investigators: UCT Prague
Express and portative detection of prohibited substances using innovative techniques: flexible and chiral SERS, selective surface extraction, artificial neural networks. (VJ01010065)
- Years: 2021 – 2025
- Principal investigator: UCT Prague
Pharmacrime – forensic identification of prohormones and counterfeid medicine (VJ01010043)
- Years: 2021 – 2025
- Principal investigator: UCT Prague
- Co-investigators: Ministry of Interior of the Czech Republic
Minimalizace vlivu residuální kontaminace po nelegální výrobě narkotik na zdraví člověka (MPO/FV30483)
- Doba řešení: 2018 – 2021
- Spoluřešitel: Ing. Martin Kuchař, Ph.D.
New synthetic drugs- complex interdisciplinar research center (MV0/VI20172020056)
- Years: 2017 – 2020
- Principal investigator: doc. Ing. Martin Kuchař, Ph.D.
Development of new methods and tools for the detection and investigation of cases of drug counterfeits for better protection of society (MV0/VI20152020048)
- Years: 2015 – 2020
- Principal investigator: doc. Ing. Martin Kuchař, Ph.D.
Minimizing the impact of residual contamination after illicit narcotics production on human health (MPO/FV30483)
- Years: 2018 – 2021
- Co-investigator: doc. Ing. Martin Kuchař, Ph.D.
Ongoing student IGA grants (University research grants):
2023
Study of degradation of endocrine disruptors in aqueous environment using photocatalysts immobilized by the airbrush method (A2_FPBT_2023_031)
- Hlavní řešitel: Ing. Barbora Walderová (Mužíková)
Finished grants I
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New chiral ionex stationary phases for enantiomeric separations (GJ16-17689Y)
- Years: 2016 – 2018
- Principal investigator: Ing. Michal Kohout, Ph.D.
New synthetic drugs (NSD) - creation of complex toxicological database, development of analytical methods for their detection including rapid immunochemical assays, their behavioral pharmacology, pharmacokinetics and biotransfomation in rats, epidemiology (MV0/VG20122015075)
- Years: 2012 – 2015
- Principal investigator: prof. Dr. RNDr. Oldřich Lapčík
- Co-investigator: Ing. Martin Kuchař, Ph.D.
Project evaluation - Excellent project results
Development of rapid amminuchemical assays for the detection of anabolic steroids (MV0/VG20112015045)
- Years: 2011 – 2015
- Principal investigator: prof. Dr. RNDr. Oldřich Lapčík
Project evaluation - Excellent project results
Finished student IGA grants:
2022
Syntéza a charakterizace nových pyridinových derivátů α-aminoketonů jako potenciálních inhibitorů KAT II (A2_FPBT_2022_069)
- Principal investigator: Ing. Hana Walaská
Photocatalytic degradation study of biologically active compounds from wastewater (A2_FPBT_2022_024)
- Principal investigator: Ing. Tereza Maříková
- Co-investigator: Ing. Barbora Mužíková (Walderová)
Regeneration of immobilized TiO2 layers in order to maintain photocatalytic activity (A2_FPBT_2022_022)
- Principal investigator: Ing. Barbora Mužíková (Walderová)
Enantioseparation of methoxphenidine by supercritical fluid chromatography hyphaneted to mass detection (A2_FPBT_2022_023)
- Principal investigator: Ing. Natalie Paškanová (Kolderová)
Application of a newly designed cell for transcorneal delivery of cannabinoids (A2_FPBT_2022_022)
- Principal investigator: Ing. Denisa Adamcová
Study of pharmacokinetics and metabolism of new dissociative anesthetics by LC-MS (A2_FCHI_2022_003)
- Principal investigator: Ing. Magdaléna Vágnerová
2021
Enantioseparation of dissociative anesthetics by supercritical fluid chromatography and study of their metabolism (A2_FPBT_2021_054)
- Principal investigator: Ing. Natalie Kolderová
Study of degradation of selected representatives of endocrine disruptors by heterogeneous photocatalysis in an aqueous environment (A2_FPBT_2021_040)
- Principal investigator: Ing. Barbora Mužíková (Walderová)
2020
Chiral separation of new psychoactive substances using supercritical fluid chromatography with mass detection (A2_FPBT_2020_039)
- Principal investigator: Ing. Natalie Kolderová
2019
Determination tryptamines and β-carboline alkaloids in amazonian psychoactive beverage Ayahuasca (A2_FPBT_2019_045)
- Principal investigator: Ing. Klára Gotvaldová
2018
Determination of new synthetic drugs in meconium of newborns (A2_FCHI_2018_032)
- Principal investigator: Mgr. Alžběta Nemeškalová
Structural and pharmacological characterization of biologically active substances (A2_FPBT_2018_022)
- Principal investigator: Ing. Bronislav Jurásek
2017
Forensic study of the possibility of delta-9-tetrahydrocannabinol (THC) intake from hemp cosmetics (A2_FCHI_2017_032)
- Principal investigator: Ing. Kateřina Hájková
Development and characterization of multianalyte immunoassays LFIA and ELISA for fast detection of new psychoactive substances (A2_FPBT_2017_058)
- Principal investigator: Ing. Lucie Fojtíková
Synthesis and bioactivity evaluation of new synthetic drugs and their metabolites (A2_FPBT_2017_017)
- Principal investigator: Ing. Bronislav Jurásek
Synthesis of novel potential inhibitors of kynurenine aminotransferase II (A2_FPBT_2017_016)
- Principal investigator: Ing. Michal Maryška
2016
Synthesis of immunogens and development of diagnostic LFIA kits for fast detection of new synthetic drugs (A2_FPBT_2016_022)
- Principal investigator: Ing. Lucie Fojtíková
Synthesis of metabolites of new synthetic drugs and evaluation of their bioactivity (A2_FPBT_2016_018)
- Principal investigator: Ing. Bronislav Jurásek
Synthesis of potential inhibitors of kynurenine aminotransferase II (A2_FPBT_2016_016)
- Principal investigator: Ing. Michal Maryška
2015
Method development for the determination of neurotransmiters in biological matrix using LC/MS (A2_FCHI_2015_011)
- Principal investigator: Ing. Barbora Pelánková
Synthesis of enzyme inhibitors of kynurenine pathway of tryptophan metabolism (A2_FPBT_2015_009)
- Principal investigator: Ing. Michal Maryška
Preparation of immunogens and characterization of antibodies for the development of immunochemical assay kits for the detection of new synthetic drugs (A2_FPBT_2015_011)
- Principal investigator: Ing. Anna Šuláková
2014
Preparation of immunogens and characterization of antibodies for the development of immunochemical assay kits for the rapid detection of new synthetic drugs (A2_FPBT_2014_015)
- Principal investigator: Ing. Anna Šuláková
2013
Synthesis of immunogens for the development of immunochemical assay kits for the rapid detection of new synthetic drugs (A2_FPBT_2013_048)
- Principal investigator: Ing. Anna Šuláková